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We used the cDNA selection technique and the polymerase chain reaction (PCR) with generic primers for the identification of new genes on the genomic clones bearing the major histocompatibility complex (<jats:italic>Mhc<\/jats:italic>) class I genes of the zebrafish (<jats:italic>Danio rerio<\/jats:italic>). We found six new genes (<jats:italic>BING1<\/jats:italic>, <jats:italic>DAXX<\/jats:italic>, <jats:italic>TAPBP<\/jats:italic>, <jats:italic>KNSL2<\/jats:italic>, <jats:italic>TAP2B<\/jats:italic> and <jats:italic>KE6<\/jats:italic>) whose orthologues are known to be linked to the <jats:italic>Mhc<\/jats:italic> class II region in humans and mice. In addition, a new zebrafish <jats:italic>Mhc<\/jats:italic> class I gene, termed <jats:italic>Dare\u2010UFA<\/jats:italic>, was detected. By contrast, a search for the human leucocyte antigen (<jats:italic>HLA<\/jats:italic>)\u2010linked <jats:italic>BING3<\/jats:italic>, <jats:italic>KE3<\/jats:italic> and <jats:italic>SACM2L<\/jats:italic> genes revealed that these loci are not located on the class I clones of the zebrafish. The zebrafish class I region contains repetitive elements with similarity to the <jats:italic>DANA<\/jats:italic>, <jats:italic>SATA<\/jats:italic> and <jats:italic>LINE<\/jats:italic> repeats, as well as <jats:italic>Tc1<\/jats:italic> transposable elements. Our findings indicate a high degree of linkage conservation between the zebrafish class I and the mammalian class II regions.<\/jats:p>","DOI":"10.1046\/j.1365-3083.2000.00729.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T20:14:23Z","timestamp":1047500063000},"page":"577-585","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Identification of Seven Genes in the Major Histocompatibility Complex Class I Region of the Zebrafish"],"prefix":"10.1111","volume":"51","author":[{"family":"S\u00fcltmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"KleinJ. 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