{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T02:30:12Z","timestamp":1768098612014,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2002,8,5]],"date-time":"2002-08-05T00:00:00Z","timestamp":1028505600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Biochemistry"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose\u2010derepressed yeast glycolysis. Three flux\u2010control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control.<\/jats:p>","DOI":"10.1046\/j.1432-1033.2002.03055.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T18:33:46Z","timestamp":1047407626000},"page":"3894-3904","source":"Crossref","is-referenced-by-count":82,"title":["Schemes of flux control in a model of <i>Saccharomyces cerevisiae<\/i> glycolysis"],"prefix":"10.1111","volume":"269","author":[{"given":"Leighton","family":"Pritchard","sequence":"first","affiliation":[]},{"given":"Douglas B.","family":"Kell","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,8,5]]},"reference":[{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3430115"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1981.0056"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1990.tb15452.x"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0141-0229(94)90033-7"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0290(19970820)55:4<592::AID-BIT2>3.0.CO;2-C"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76667-7"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01527.x"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3450321"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.10098"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.21.14551"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.030539197"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00197-8"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5266(00)00072-8"},{"key":"e_1_2_16_15_2","first-page":"563","article-title":"Gepasi \u2013 a software package for modelling the dynamics, steady\u2010states and control of biochemical and other systems","volume":"9","author":"Mendes P.","year":"1993","journal-title":"Comput. Applicat. Biosci."},{"key":"e_1_2_16_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(97)01103-1"},{"key":"e_1_2_16_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/14.10.869"},{"key":"e_1_2_16_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-4072-0_1"},{"key":"e_1_2_16_19_2","first-page":"65","article-title":"The control of flux","volume":"27","author":"Kacser H.","year":"1973","journal-title":"Symposia Soc. Exp. Biol."},{"key":"e_1_2_16_20_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0230341"},{"key":"e_1_2_16_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1161-4"},{"key":"e_1_2_16_22_2","volume-title":"Understanding the Control of Metabolism","author":"Fell D.A.","year":"1997"},{"key":"e_1_2_16_23_2","volume-title":"Introductory Statistics","author":"Weiss N.A.","year":"1991"},{"key":"e_1_2_16_24_2","volume-title":"Numerical Recipes in C, the Art of Scientific Computing","author":"Press W.H.","year":"1992"},{"key":"e_1_2_16_25_2","volume-title":"Chemometrics: Statistics and Computer Application in Analytical Chemistry","author":"Otto M.","year":"1999"},{"key":"e_1_2_16_26_2","volume-title":"Multivariate Calibration","author":"Martens H.","year":"1989"},{"key":"e_1_2_16_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-1904-8"},{"key":"e_1_2_16_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-48773-5_3"},{"key":"e_1_2_16_29_2","volume-title":"Lipid Analysis of Oils and Fats","author":"Jones A.","year":"1998"},{"key":"e_1_2_16_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/43199"},{"key":"e_1_2_16_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/17672"},{"key":"e_1_2_16_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(91)90021-M"},{"key":"e_1_2_16_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.60.4.641-696.1996"},{"key":"e_1_2_16_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00430362"},{"key":"e_1_2_16_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/83496"},{"key":"e_1_2_16_36_2","doi-asserted-by":"crossref","first-page":"25502","DOI":"10.1016\/S0021-9258(18)47278-X","article-title":"Control of glucose utilization in working perfused rat\u2010heart","volume":"269","author":"Kashiwaya Y.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"e_1_2_16_37_2","volume-title":"Biochemistry (Fourth Edition).","author":"Stryer L.","year":"1995"},{"key":"e_1_2_16_38_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1981.0059"},{"key":"e_1_2_16_39_2","first-page":"205","volume-title":"The Yeasts","author":"Gancedo C.","year":"1989"},{"key":"e_1_2_16_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01220.x"},{"key":"e_1_2_16_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.63.3.554-569.1999"},{"key":"e_1_2_16_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R000016200"},{"key":"e_1_2_16_43_2","first-page":"45","volume-title":"Yeast Sugar Metabolism: Biochemistry, Genetics, Biotechnology and Applications","author":"Ciriacy M.","year":"1997"},{"key":"e_1_2_16_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.tb02400.x"},{"key":"e_1_2_16_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(98)01637-0"},{"key":"e_1_2_16_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.320050305"},{"key":"e_1_2_16_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.4.953-958.1994"},{"key":"e_1_2_16_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.15.4673-4675.1999"},{"key":"e_1_2_16_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)76043-2"},{"key":"e_1_2_16_50_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-145-12-3447"},{"key":"e_1_2_16_51_2","first-page":"97","volume-title":"Yeast Sugar Metabolism: Biochemistry, Genetics, Biotechnology and Applications","author":"Kopperschlager G.","year":"1997"},{"key":"e_1_2_16_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00134a028"},{"key":"e_1_2_16_53_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-143-9-3055"},{"key":"e_1_2_16_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(98)01305-5"},{"key":"e_1_2_16_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.320050408"}],"container-title":["European Journal of Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1432-1033.2002.03055.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1432-1033.2002.03055.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1432-1033.2002.03055.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:52:03Z","timestamp":1697457123000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1046\/j.1432-1033.2002.03055.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":54,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1046\/j.1432-1033.2002.03055.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1432-1033.2002.03055.x","archive":["Portico"],"relation":{},"ISSN":["0014-2956","1432-1033"],"issn-type":[{"value":"0014-2956","type":"print"},{"value":"1432-1033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}