{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:07:00Z","timestamp":1773644820861,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,9,27]],"date-time":"2002-09-27T00:00:00Z","timestamp":1033084800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study demonstrates that pharmacological manipulation of the dopamine (DA) receptors can modulate the size of the axonal tree of substantia nigra pars compacta (SNpc) neurons in mice. Pharmacological blockade or genetic ablation of the D2 receptor (D2R) resulted in sprouting of DA SNpc neurons whereas treatment with a D2 agonist resulted in pruning of the terminal arbor of these neurons. Agents such as cocaine, that indirectly stimulate D2R, also resulted in reduced terminal arbor. Specific D1 agonists or antagonists had no effect on the density of DA terminals in the striatum. We conclude that the D2 receptor has a central role in regulating the size of the terminal arbor of nigrostriatal neurons. These findings have implications relating to the use of dopaminergic agonists in the management of Parkinson's disease and in controlling plasticity following injury, loss or transplantation of DA neurons.<\/jats:p>","DOI":"10.1046\/j.1460-9568.2002.02132.x","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T14:49:01Z","timestamp":1046962141000},"page":"787-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Effects of long\u2010term treatment with dopamine receptor agonists and antagonists on terminal arbor size"],"prefix":"10.1111","volume":"16","author":[{"given":"C. L.","family":"Parish","sequence":"first","affiliation":[]},{"given":"D.","family":"Stanic","sequence":"additional","affiliation":[]},{"given":"J.","family":"Drago","sequence":"additional","affiliation":[]},{"given":"E.","family":"Borrelli","sequence":"additional","affiliation":[]},{"given":"D. I.","family":"Finkelstein","sequence":"additional","affiliation":[]},{"given":"M. K.","family":"Horne","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,10,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/29.6.7252134"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio245150a0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/377424a0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.9.1937"},{"key":"e_1_2_6_6_1","volume-title":"Dopamine\u2010Containing Systems in the CNS","author":"Bjorklund A.","year":"1984"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01391-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64041669.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1990.tb02967.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00050-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960101)364:1<6::AID-CNE2>3.0.CO;2-9"},{"key":"e_1_2_6_12_1","volume-title":"The Biochemical Basis of Neuropharmacology","author":"Cooper J.R.","year":"1996"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(82)90019-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12564"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017313"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901800310"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00009-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(88)90137-X"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-12-03915.1987"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1988.tb00954.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90871-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.1523\/JNEUROSCI.18-15-05614.1998","article-title":"Induction of interleukin\u20101 associated with compensatory dopaminergic sprouting in the denervated striatum of young mice: model of aging and neurodegenerative disease","volume":"18","author":"Ho A.","year":"1998","journal-title":"J. Neurosci."},{"key":"e_1_2_6_23_1","first-page":"1285","article-title":"Clearance and diffusion of locally applied dopamine in normal and 6\u2010hydroxydopamine\u2010lesioned rat striatum","volume":"263","author":"Van Horne C.","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_24_1","first-page":"140","article-title":"Parkinson's disease and the adaptive capacity of the nigrostriatal dopamine system: possible neurochemical mechanisms","volume":"60","author":"Hornykiewicz O.","year":"1993","journal-title":"Adv. Neurol."},{"key":"e_1_2_6_25_1","volume-title":"Principles of Neural Science","author":"Kandel E.R.","year":"1991"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/277093a0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1964"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.19.8861"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7152"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.1.189"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960603)369:3<361::AID-CNE3>3.0.CO;2-3"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90894-2"},{"key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1523\/JNEUROSCI.21-14-05147.2001","article-title":"The role of dopamine receptors in regulating the size of axonal arbours","volume":"21","author":"Parish C.L.","year":"2001","journal-title":"J. Neurosci."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422004"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0084241"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1054"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/35041572"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.5.1859"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902960102"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960617)370:1<11::AID-CNE2>3.0.CO;2-O"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092310411"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00284-X"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90112-N"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050190062015"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1460-9568.2002.02132.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1460-9568.2002.02132.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:46:15Z","timestamp":1696257975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1460-9568.2002.02132.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1046\/j.1460-9568.2002.02132.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1460-9568.2002.02132.x","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]},"assertion":[{"value":"2002-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}