{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:04:12Z","timestamp":1761523452557},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,1,18]],"date-time":"2002-01-18T00:00:00Z","timestamp":1011312000000},"content-version":"vor","delay-in-days":657,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p> <jats:bold>Abstract:<\/jats:bold> The interleukin (IL)\u20106 family cytokines utilize membrane\nglycoprotein gp130 in common as a critical signal\u2010transducing receptor\ncomponent. IL\u201011, a cytokine initially identified as a plasmacytoma growth\nfactor, belongs to this family. We show here that IL\u201011 and its cognate\nreceptor components are expressed in fetal mouse neuroepithelial cells. We\nalso show that after 4 days of culture with IL\u201011, cells with typical\nastrocytic morphologies expressing glial fibrillary acidic protein (GFAP; a\nmarker for astrocytes) come out. This differentiation process is totally\ndependent on the gp130\u2010mediated signal\u2010transduction pathway involving\nactivation of a latent cytoplasmic transcription factor, STAT3 (for\n<jats:styled-content>s<\/jats:styled-content>ignal <jats:styled-content>t<\/jats:styled-content>ransducer and <jats:styled-content>a<\/jats:styled-content>ctivator of\n<jats:styled-content>t<\/jats:styled-content>ranscription <jats:styled-content>3<\/jats:styled-content>), because (a) IL\u201011\u2010induced astrocyte differentiation is not observed when neuroepithelial cells prepared from gp130\u2010deficient mice were used, (b) stimulation of neuroepithelial cells by IL\u201011 rapidly induces tyrosine\u2010phosphorylation of STAT3, and (c) transfection of neuroepithelial cells with a dominant\u2010negative form of STAT3 inhibits IL\u201011\u2010induced activation of the GFAP gene promoter. We have further identified, in the GFAP promoter region, a STAT3 site at which nucleotide substitutions almost completely abolished the IL\u201011\u2010induced GFAP promoter activation. Taken together, it is suggested that IL\u201011 contributes to astrocytogenesis in fetal brain via activation of gp130 and STAT3.<\/jats:p>","DOI":"10.1046\/j.1471-4159.2000.0741498.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T06:44:22Z","timestamp":1047451462000},"page":"1498-1504","source":"Crossref","is-referenced-by-count":45,"title":["Astrocyte Differentiation of Fetal Neuroepithelial Cells by Interleukin\u201011 via Activation of a Common Cytokine Signal Transducer, gp130, and a Transcription Factor, STAT3"],"prefix":"10.1111","volume":"74","author":[{"given":"Makoto","family":"Yanagisawa","sequence":"first","affiliation":[]},{"given":"Kinichi","family":"Nakashima","sequence":"additional","affiliation":[]},{"given":"Hirokazu","family":"Arakawa","sequence":"additional","affiliation":[]},{"given":"Kazuhiro","family":"Ikenaka","sequence":"additional","affiliation":[]},{"given":"Kanji","family":"Yoshida","sequence":"additional","affiliation":[]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[]},{"given":"Tatsuhiro","family":"Hisatsune","sequence":"additional","affiliation":[]},{"given":"Tetsuya","family":"Taga","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,1,18]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.1998.00762.x"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5337.477"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8390097"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.18.030195.001111"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.24.3129"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.11.4959"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90333-6"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/378724a0"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90094-T"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/365027a0"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.66"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/362062a0"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.9.3963"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8511589"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-13-05429.1999"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5413.479"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00997-7"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.48.30986"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-10-03620.1998"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19960215)43:4<403::AID-JNR2>3.0.CO;2-J"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-11-04565.1992"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81166-6"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67010001.x"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.797"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90438-8"},{"key":"e_1_2_11_27_2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1182\/blood.V93.3.804","article-title":"Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit.","volume":"93","author":"Tanaka M.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_11_28_2","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1242\/dev.121.5.1283","article-title":"Targeted disruption of the low\u2010affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.","volume":"121","author":"Ware C.B.","year":"1995","journal-title":"Development"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00447-4"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530110617"},{"key":"e_1_2_11_31_2","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.4049\/jimmunol.151.5.2555","article-title":"Involvement of IL\u20106 signal transducer gp130 in IL\u201011\u2010mediated signal transduction.","volume":"151","author":"Yin T.","year":"1993","journal-title":"J. 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