{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:47:46Z","timestamp":1762159666796},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,12,20]],"date-time":"2001-12-20T00:00:00Z","timestamp":1008806400000},"content-version":"vor","delay-in-days":294,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p>In order to determine whether <jats:sc>l<\/jats:sc>\u2010DOPA\u2010derived extracellular dopamine (DA) in the striatum with dopaminergic denervation is affected by activation of serotonin autoreceptors (5\u2010HT<jats:sub>1A<\/jats:sub> and 5\u2010HT<jats:sub>1B<\/jats:sub> receptors), we applied <jats:italic>in vivo<\/jats:italic> brain microdialysis technique to 6\u2010hydroxydopamine\u2010lesioned rats and examined the effects of the selective 5\u2010HT<jats:sub>1A<\/jats:sub> receptor agonist 8\u2010hydroxy\u20102\u2010(di\u2010<jats:italic>n<\/jats:italic>\u2010propylamino)tetralin (8\u2010OH\u2010DPAT) and the selective 5\u2010HT<jats:sub>1B<\/jats:sub> receptor agonist CGS\u201012066\u2003A on <jats:sc>l<\/jats:sc>\u2010DOPA\u2010derived extracellular DA levels. Single <jats:sc>l<\/jats:sc>\u2010DOPA injection (50\u2003mg\/kg i.p.) caused a rapid increase and a following decrease of extracellular DA, with a peak value at 100\u2003min after <jats:sc>l<\/jats:sc>\u2010DOPA injection. Pretreatment with both 0.3\u2003mg\/kg and 1\u2003mg\/kg 8\u2010OH\u2010DPAT (i.p.) significantly attenuated an increase in <jats:sc>l<\/jats:sc>\u2010DOPA\u2010derived extracellular DA and the times of peak DA levels were prolonged to 150\u2003min and 225\u2003min after <jats:sc>l<\/jats:sc>\u2010DOPA injection, respectively. These 8\u2010OH\u2010DPAT\u2010induced changes in <jats:sc>l<\/jats:sc>\u2010DOPA\u2010derived extracellular DA were antagonized by further pretreatment with WAY\u2010100635, a selective 5\u2010HT<jats:sub>1A<\/jats:sub> antagonist. In contrast, intrastriatal perfusion with the 5\u2010HT<jats:sub>1B<\/jats:sub> agonist CGS\u201012066\u2003A (10\u2003n<jats:sc>m<\/jats:sc> and 100\u2003n<jats:sc>m<\/jats:sc>) did not induce any changes in <jats:sc>l<\/jats:sc>\u2010DOPA\u2010derived extracellular DA. Thus, stimulation of 5\u2010HT<jats:sub>1A<\/jats:sub> but not 5\u2010HT<jats:sub>1B<\/jats:sub> receptors attenuated an increase in extracellular DA derived from exogenous <jats:sc>l<\/jats:sc>\u2010DOPA. These results support the hypothesis that serotonergic neurons are\u00a0primarily responsible for the storage and release of DA\u00a0derived from exogenous <jats:sc>l<\/jats:sc>\u2010DOPA in the absence of dopaminergic neurons.<\/jats:p>","DOI":"10.1046\/j.1471-4159.2001.00184.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T06:51:50Z","timestamp":1047451910000},"page":"1346-1353","source":"Crossref","is-referenced-by-count":120,"title":["Activation of 5\u2010HT<sub>1A<\/sub> but not 5\u2010HT<sub>1B<\/sub> receptors attenuates an increase in extracellular dopamine derived from exogenously administered <scp>l<\/scp>\u2010DOPA in the striatum with nigrostriatal denervation"],"prefix":"10.1111","volume":"76","author":[{"given":"Kazuya","family":"Kannari","sequence":"first","affiliation":[]},{"given":"Hiroshi","family":"Yamato","sequence":"additional","affiliation":[]},{"given":"Huo","family":"Shen","sequence":"additional","affiliation":[]},{"given":"Masahiko","family":"Tomiyama","sequence":"additional","affiliation":[]},{"given":"Toshihiro","family":"Suda","sequence":"additional","affiliation":[]},{"given":"Muneo","family":"Matsunaga","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91318-B"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91511-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11817-g"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90658-D"},{"key":"e_1_2_6_6_1","first-page":"373","article-title":"Serotonin\u2010facilitated release in vivo: pharmacological characterization","volume":"265","author":"Benloucif S.","year":"1993","journal-title":"J.\u00a0Pharmacol. 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