{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:06:56Z","timestamp":1770822416790,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":4349,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[1996,11,12]]},"abstract":"<jats:p>BACKGROUND: Fever has been identified as a major cause of platelet refractoriness. However, it is regularly attended by the administration of antibiotics, and thus it cannot be determined whether fever, the administration of antibiotics, or both are responsible for the reduced platelet increment. The present study was undertaken to discern the effect of body temperature and antibiotics on transfusion success. STUDY DESIGN AND METHODS: Single\u2010donor platelet transfusions (n = 400) were monitored retrospectively. Besides other influencing factors (e.g., spleen size, number of previous transfusions, diagnosis, bone marrow transplantation), body temperature and the administration of antibiotics were documented from the patients' records. To distinguish the effects of fever and antibiotics, a general mixed model of variance was used for analysis. RESULTS: Besides the well\u2010known factors of splenomegaly, hepatomegaly, bone marrow transplantation, and pretransfusion storage time, both body temperature and antibiotics independently reduced the corrected count increment. Among the various antibiotics, amphotericin B, ciprofloxacin, and vancomycin had the greatest influence. CONCLUSION: The administration of antibiotics has a negative effect on the corrected count increment, independent of the presence of fever. Besides amphotericin B, which has previously been shown to influence the corrected count increment, vancomycin and ciprofloxacin reduce it significantly. Because these antibiotics are widely used in patients with bone marrow failure, these observations should be proven by further prospective in vivo and in vitro studies.<\/jats:p>","DOI":"10.1046\/j.1537-2995.1996.36111297091736.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T22:33:16Z","timestamp":1047508396000},"page":"952-954","source":"Crossref","is-referenced-by-count":43,"title":["Influence of antibiotics on posttransfusion platelet increment"],"prefix":"10.1111","volume":"36","author":[{"given":"M.","family":"B\u00f6ck","sequence":"first","affiliation":[]},{"given":"K.\u2010H.","family":"Muggenthaler","sequence":"additional","affiliation":[]},{"given":"U.","family":"Schmidt","sequence":"additional","affiliation":[]},{"given":"M. U.","family":"Heim","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"e_1_2_2_2_2","first-page":"1","volume-title":"Immunologic aspects of platelet transfusion","author":"Lee EJ","year":"1985"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1994.tb00310.x"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31591263191.x"},{"key":"e_1_2_2_5_2","first-page":"95","volume-title":"Transfusion medicine in the 1990's","author":"Slichter SJ.","year":"1990"},{"key":"e_1_2_2_6_2","volume-title":"The BMDP Statistical Software Package (Release 7)","author":"BMDP","year":"1992"},{"key":"e_1_2_2_7_2","first-page":"350","article-title":"[Clinical conditions influencing posttransfusion platelet increment] (Engl abstract)","volume":"22","author":"Bock M.","year":"1995","journal-title":"Infusionsther Transfusionsmed"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1982.22182154213.x"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1991.tb00891.x"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.2.383.383"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32192116432.x"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32192116437.x"},{"key":"e_1_2_2_13_2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1182\/blood.V75.2.518.518","article-title":"Vancomycindependent antibodies associated with thrombocytopenia and refractoriness to platelet transfusion in patients with leukemia","volume":"75","author":"Christie DJ","year":"1990","journal-title":"Blood"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1537-2995.1996.36111297091736.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1537-2995.1996.36111297091736.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T08:59:16Z","timestamp":1693472356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1537-2995.1996.36111297091736.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11,12]]},"references-count":12,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[1996,11,12]]}},"alternative-id":["10.1046\/j.1537-2995.1996.36111297091736.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1537-2995.1996.36111297091736.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11,12]]}}}