{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:26:01Z","timestamp":1762658761949},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,3,7]],"date-time":"2002-03-07T00:00:00Z","timestamp":1015459200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p><jats:bold>Summary.<\/jats:bold> Essential thrombocythaemia (ET) is a chronic myeloproliferative disorder (MPD) characterized by an elevated platelet count and no identifiable underlying primary cause. According to the diagnostic criteria of the Polycythemia Vera Study Group (PVSG<jats:bold>)<\/jats:bold>, ET lacks features diagnostic for other MPDs, including the Philadelphia chromosome <jats:bold>(<\/jats:bold>Ph<jats:bold>)<\/jats:bold> or bcr\u2013abl rearrangement. Recently, some authors have reported bcr\u2013abl transcript positivity in ET patients, but these findings remain controversial. The aim of this study was to investigate whether the bcr\u2013abl transcript could be found in ET patients and to verify the hypothesis of a new ET variant. ET patients (<jats:italic>n<\/jats:italic>\u2003=\u2003121) with a median age at diagnosis of 55\u2003years were enrolled. The bcr\u2013abl transcript status was examined by multiplex reverse transcription\u2013polymerase chain reaction. Only two cases were positive for bcr\u2013abl, one of which had the Ph at diagnosis. The positive bcr\u2013abl transcript was associated, in both cases, with mild basophilia at diagnosis. After a median follow\u2010up of 43\u2003months (0\u2013309\u2003months), two patients in the bcr\u2013abl\u2010negative group developed Ph and bcr\u2013abl\u2010negative acute myeloid leukaemia (AML). In contrast, one of the two patients in the bcr\u2013abl\u2010positive group died from AML 13\u2003years after diagnosis. In conclusion, our data on a large group of patients shows the rarity of the bcr\u2013abl transcript in well\u2010established ET. However, a subset of patients with apparent ET and basophilia may express the transcript and may constitute a novel entity intermediate between chronic myeloid leukaemia (CML) and typical ET. A prospective study is warranted in order to define better the clinical and biological characteristics of bcr\u2013abl\u2010expressing ET.<\/jats:p>","DOI":"10.1046\/j.0007-1048.2002.03343.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:43:05Z","timestamp":1047364985000},"page":"812-816","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Typical essential thrombocythaemia does not express bcr\u2013abelson fusion transcript"],"prefix":"10.1111","volume":"116","author":[{"given":"G.","family":"Damaj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Delabesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Le 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