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Moreover, there was a radical reduction in B\u2010cell lymphopoiesis, evident at the pre\u2010B\u2010cell stage, with a twofold increase of lymphoid cells \u2018in cycle\u2019 in transgenic bone marrow, indicative of major changes in haematopoietic homeostasis. This system may provide a generic protocol for conditional, lineage\u2010specific cell ablation with available tissue\u2010specific promoters for any eukaryotic developmental system, and provide a window on early T\u2010cell development.<\/jats:p>","DOI":"10.1046\/j.0019-2805.2002.01376.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T02:30:50Z","timestamp":1047436250000},"page":"306-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Conditional ablation of T\u2010cell development by a novel viral ion channel transgene"],"prefix":"10.1111","volume":"105","author":[{"given":"Claire A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Mathers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J.","family":"Hay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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