{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:26:00Z","timestamp":1792146360844,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,3,22]],"date-time":"2002-03-22T00:00:00Z","timestamp":1016755200000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold>  <jats:italic>Background\/Aim<\/jats:italic>: To investigate the mode of progression of combined hepatocellular carcinoma and cholangiocarcinoma (cHCC\u2010CC). <jats:italic>Methods:<\/jats:italic> An immunohistochemical study for E\u2010cadherin (ECD) and alpha\u2010 and beta\u2010catenins was performed on 29 cases of cHCC\u2010CC. <jats:italic>Results:<\/jats:italic> Reduced expression of ECD was significantly correlated with the tumour grade of the hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) components, intrahepatic metastasis (IM) of HCC, IM of CC, and vascular invasion of CC (p\u2003&lt;\u20030.05, respectively). There was a significant relationship between the reduced expression of beta\u2010catenin and the tumour grade of HCC components (p\u2003&lt;\u20030.05). Cases showing concurrent intrahepatic metastasis composed of HCC, CC, or both, numbered 6, 5, and 2, respectively. The expression patterns of ECD and beta\u2010catenin of IM were similar to those of primary lesion in most cases. On the other hand, expression of ECD and beta\u2010catenin of IM of HCC component were preserved, even though those of the primary sites were reduced in two cases and one case, respectively. ECD and beta\u2010catenin were significantly correlated with tumour differentiation and tumour progression. <jats:italic>Conclusions:<\/jats:italic> Preserved or recovered ECD and beta\u2010catenin expression may be of beneficial effect for re\u2010establishing the tissue architecture at the metastatic site.<\/jats:p>","DOI":"10.1046\/j.0106-9543.2001.01580.x","type":"journal-article","created":{"date-parts":[[2004,12,27]],"date-time":"2004-12-27T10:17:10Z","timestamp":1104142630000},"page":"43-50","source":"Crossref","is-referenced-by-count":31,"title":["The mode of tumour progression in combined hepatocellular carcinoma and cholangiocarcinoma: an immunohistochemical analysis of E\u2010cadherin, alpha\u2010catenin and 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