{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:57:27Z","timestamp":1783634247860,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,3,5]],"date-time":"2002-03-05T00:00:00Z","timestamp":1015286400000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>objective<\/jats:bold> \u2002The hyperparathyroidism\u2013jaw tumour (HPT\u2013JT) syndrome is one of the familial disorders characterized by primary hyperparathyroidism and has been linked to the chromosomal region of 1q32\u2013q21. The parathyroid tumours related to this syndrome have shown loss of wild\u2010type alleles at this locus suggesting that inactivation of a tumour suppressor gene might be responsible for the disease. In the majority of these tumours cysts are a prominent feature. By loss of heterozygosity (LOH) studies, we investigated the region of interest in an attempt to clarify its possible role in a series of cystic sporadic parathyroid adenomas.<\/jats:p><jats:p><jats:bold>design and subjects<\/jats:bold> \u2002A total of 30 patients diagnosed with sporadic hyperparathyroidism were included in the study, genotyped with 17 polymorphic microsatellite markers at chromosome 1q, and additional markers from 1p and 11q13 which are commonly involved in sporadic parathyroid tumours. The cystic parathyroid tumours were characterized clinically, and immunohistochemistry against PTH was carried out to confirm the parathyroid origin of the cysts.<\/jats:p><jats:p><jats:bold>results<\/jats:bold> \u2002LOH was found in six of 30 tumours (20%) on 1q, six of 30 tumours (20%) on 1p and five of 30 tumours (17%) on 11q13. We found a significant correlation between allelic alterations and the clinical parameters, tumour weight and PTH. Furthermore, we found a significant difference between tumour weight and PTH in cases of cystic parathyroid tumours compared with unselected sporadic cases.<\/jats:p><jats:p><jats:bold>conclusions<\/jats:bold> \u2002These results suggest that cystic parathyroid tumours might represent a new subgroup among parathyroid tumours based on the genetic and clinical findings. Loss of heterozygosity at 1q further supports the presence of a tumour suppressor gene at this locus.<\/jats:p>","DOI":"10.1046\/j.0300-0664.2001.01469.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T10:52:27Z","timestamp":1047379947000},"page":"261-269","source":"Crossref","is-referenced-by-count":16,"title":["Genetic and clinical characterization of sporadic cystic parathyroid tumours"],"prefix":"10.1111","volume":"56","author":[{"given":"Andrea","family":"Villablanca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Farnebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin Tean","family":"Teh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars\u2010Ove","family":"Farnebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"H\u00f6\u00f6g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00049-1"},{"key":"e_1_2_6_3_1","first-page":"543","article-title":"The cyclin D1\/PRAD1 oncogene in human neoplasia","volume":"43","author":"Arnold A.","year":"1996","journal-title":"Journal of Investigative Medicine"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803173181102"},{"key":"e_1_2_6_5_1","first-page":"457","volume-title":"The Parathyroids","author":"Bilezikian J.P.","year":"1994"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80039-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.8.2960"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.6051"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5311.404"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870130103"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01010.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.10.3775"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050369"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.8.2627"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450415"},{"key":"e_1_2_6_16_1","first-page":"615","article-title":"Immunocytochemical localization of parathyroid hormone in bovine parathyroid glands and human parathyroid adenomas","volume":"94","author":"Futrell J.M.","year":"1979","journal-title":"American Journal of Pathology"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.1999.01587.x"},{"key":"e_1_2_6_18_1","first-page":"381","volume-title":"Functional Endocrine Pathology","author":"Grimelius L.","year":"1998"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1449"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0897-375"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/302259"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.5.1736"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.1.165"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64568-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.5.1752"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/332085a0"},{"key":"e_1_2_6_27_1","first-page":"69","article-title":"Immunohistochemical localization of chromogranin in normal and neoplastic endocrine tissues","volume":"22","author":"Lloyd R.V.","year":"1987","journal-title":"Pathology Annual"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90357-3"},{"key":"e_1_2_6_29_1","first-page":"435","volume-title":"The Parathyroids","author":"Mallette L.E.","year":"1994"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-1-54"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/350512a0"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.5.1766"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-3-2-218"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215549704500301"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59655-1"},{"key":"e_1_2_6_36_1","first-page":"944","article-title":"Hereditary hyperparathyroidism\u2013jaw tumor syndrome: the endocrine tumor gene HRPT2 maps to chromosome 1q21\u2013q31","volume":"56","author":"Szabo J.","year":"1995","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.10.3663"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.9.1330"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1086\/302097"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.12.4204"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.6.2114"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.7.1177"},{"key":"e_1_2_6_43_1","first-page":"311","article-title":"Parathyroid cysts","volume":"18","author":"Turner A.","year":"1989","journal-title":"Journal of Otolaryngology"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00633.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.2.230"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.0300-0664.2001.01469.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.0300-0664.2001.01469.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.0300-0664.2001.01469.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T17:37:20Z","timestamp":1697564240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.0300-0664.2001.01469.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1046\/j.0300-0664.2001.01469.x"],"URL":"https:\/\/doi.org\/10.1046\/j.0300-0664.2001.01469.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}