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In this study, we show that CD4<jats:sup>+<\/jats:sup> T cells cross\u2010compete for antigenic complexes on the surface of APC, inhibiting activation of other potentially reactive T cells of the same and differing specificities. T cells with either a higher affinity receptor for antigen or which have undergone prior activation compete more efficiently than low affinity or resting T cells. This implies that T\u2010cell avidity for the APC is primarily responsible for the competitive advantage. We also provide evidence that the mechanism for competition is steric hindrance of the surface of the APC, rather than T\u2010cell\u2010mediated sequestration or internalization of antigenic complexes. This is because removal of competing T cells restores the antigenic potential of the APC, and APC fixation does not abrogate competition. Demonstration that competition for access to APC can also occur <jats:italic>in vivo<\/jats:italic> suggests that this process may represent a physiologically important mechanism for influencing the quality and quantity of CD4<jats:sup>+<\/jats:sup> T\u2010cell responses.<\/jats:p>","DOI":"10.1046\/j.0818-9641.2004.01233.x","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T08:17:39Z","timestamp":1082017059000},"page":"103-111","source":"Crossref","is-referenced-by-count":19,"title":["CD4<sup>+<\/sup> T cells cross\u2010compete for MHC class II\u2010restricted peptide antigen complexes on the surface of antigen presenting cells"],"prefix":"10.1111","volume":"82","author":[{"given":"John D","family":"Hayball","sequence":"first","affiliation":[{"name":"Dame Roma Mitchell Cancer Research Laboratories, Hanson Institute  Frome Road Adelaide South Australia 5000 Australia"},{"name":"Department of Medicine, University of Adelaide  Frome Road Adelaide South Australia 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce W S","family":"Robinson","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Queen Elizabeth II Medical School  Nedlands Perth Western Australia 6009 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Lake","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Queen Elizabeth II Medical School  Nedlands Perth Western Australia 6009 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb00961.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/381751a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00076-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7535476"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.701"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80048-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/13.11.1383"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.1999.00794.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.4049\/jimmunol.161.9.4499","article-title":"Immunodominance in the CTL response against minor histocompatibility antigens. interference between responding T cells, rather than with presentation of epitopes","volume":"161","author":"Wolpert EZ","year":"1998","journal-title":"J. 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