{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:56:22Z","timestamp":1779346582235,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,11,7]],"date-time":"2003-11-07T00:00:00Z","timestamp":1068163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> The eight\u2010twenty\u2010one (ETO) homologues, represented by ETO, myeloid transforming gene\u2010related protein 1 (MTGR1) and myeloid transforming gene chromosome 16 (MTG16), are nuclear repressor proteins. ETO is part of the fusion protein acute myeloid leukaemia (AML)1\u2010ETO, resulting from the translocation (8;21). Similarly, MTG16 is disrupted to become part of AML1\/MTG16 in t(16;21). The aberrant expression of these chimeras could affect interplay between ETO homologues and contribute to the leukaemogenic process. We investigated possible interactions between the ETO homologues. Ectopic co\u2010expression in COS\u2010cells resulted in heterodimerisation of the various ETO homologues suggesting that they may co\u2010operate. Similarly, the chimeric oncoprotein AML1\u2010ETO interacted with both MTGR1 and MTG16. However, results from cell lines endogenously expressing more than one ETO homologue did not demonstrate co\u2010precipitation. Results from IP\u2010Western and size determination by gel filtration of deletion mutants expressed in COS\u2010cells, indicated an important role of the HHR domain for oligomerisation. A role was also suggested for the Nervy domain in the homologue interactions. Our results suggest that ETO homologues can interact with each other as well as with AML1\u2010ETO, although it is unclear as to what extent these interactions occur <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1046\/j.0902-4441.2003.00166.x","type":"journal-article","created":{"date-parts":[[2003,11,7]],"date-time":"2003-11-07T20:38:38Z","timestamp":1068237518000},"page":"439-447","source":"Crossref","is-referenced-by-count":15,"title":["Interactions between the leukaemia\u2010associated ETO homologues of nuclear repressor proteins"],"prefix":"10.1111","volume":"71","author":[{"given":"Sofia Rondin","family":"Lindberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann\u2010Maj","family":"Persson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,7]]},"reference":[{"key":"e_1_2_20_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5340.1059"},{"key":"e_1_2_20_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205315"},{"key":"e_1_2_20_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.4.1974"},{"key":"e_1_2_20_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.7.1825.1825"},{"key":"e_1_2_20_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10431"},{"key":"e_1_2_20_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05933.x"},{"key":"e_1_2_20_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90384-K"},{"key":"e_1_2_20_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/scdb.2000.0183"},{"key":"e_1_2_20_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80986-1"},{"key":"e_1_2_20_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3444"},{"key":"e_1_2_20_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.11.5697"},{"key":"e_1_2_20_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.22.12359"},{"key":"e_1_2_20_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81389-6"},{"key":"e_1_2_20_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.8.5558"},{"key":"e_1_2_20_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11895"},{"key":"e_1_2_20_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9650"},{"key":"e_1_2_20_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.2.607.bloodjournal862607"},{"key":"e_1_2_20_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.6.3324"},{"key":"e_1_2_20_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00014-7"},{"key":"e_1_2_20_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm726"},{"key":"e_1_2_20_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.12.7176"},{"key":"e_1_2_20_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.12.7185"},{"key":"e_1_2_20_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.18.10860"},{"key":"e_1_2_20_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010582200"},{"key":"e_1_2_20_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.5.3635"},{"key":"e_1_2_20_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.1.322"},{"key":"e_1_2_20_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.2.846"},{"key":"e_1_2_20_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.11.4028"},{"key":"e_1_2_20_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00481-3"},{"key":"e_1_2_20_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00141-3"},{"key":"e_1_2_20_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.6.2075-2086.2000"},{"key":"e_1_2_20_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10548"},{"key":"e_1_2_20_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.16.5658-5666.2001"},{"key":"e_1_2_20_35_2","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1182\/blood.V88.5.1813.1813","article-title":"ETO 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