{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:26:48Z","timestamp":1787675208580,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":142,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This case report describes a distinctive deep cutaneous lesion in a 1\u2010year\u2010old Quarter Horse filly with hyperelastosis cutis. The horse had a typical clinical presentation of hyperelastic skin associated with a 6\u2010month history of cutaneous wounds that developed following minor cutaneous trauma. Punch biopsies of skin from the affected horse were thinner than similar biopsies from an age\u2010 and breed\u2010matched control. Significant microscopic lesions were not seen in cutaneous punch biopsies stained with haematoxylin and eosin and Masson\u2019s trichrome stains, but the ultrastructure of the dermis from the affected horse was characterized by variation in collagen fibre diameter and loose packing of collagen fibres within bundles. The horse was euthanized and necropsied, and full\u2010thickness sections of skin were collected and examined microscopically. Affected skin was of normal thickness; however, the deep dermis contained a distinctive horizontal linear zone in which separation of collagen bundles resulted in the formation of large empty cleft\u2010like spaces between the upper and lower regions of the deep dermis. We suggest the term \u2018zonal dermal separation\u2019 for this microscopic lesion. Incisional full\u2010thickness skin biopsies should be taken in suspected cases of equine hyperelastosis cutis because punch biopsies may not obtain enough deep dermis to adequately represent pathological change in the skin of horses with this disorder.<\/jats:p>","DOI":"10.1046\/j.0959-4493.2001.00256.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T23:30:16Z","timestamp":1047511816000},"page":"219-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Zonal dermal separation: a distinctive histopathological lesion associated with hyperelastosis cutis in a Quarter Horse"],"prefix":"10.1111","volume":"12","author":[{"given":"Sabrina H.","family":"Brounts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Rashmir\u2010Raven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon S.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340114"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1994.9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000413484"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1997.9694768"},{"key":"e_1_2_5_6_2","unstructured":"Bridges C.H.&McMullan W.C.Dermatosparaxis in Quarter horses.Proceedings of the 35th Annual Meeting of the American College of Veterinary Pathologists. Toronto Canada1984:12."},{"key":"e_1_2_5_7_2","first-page":"253","article-title":"An inherited connective disease in the horse","volume":"59","author":"Hardy M.H.","year":"1988","journal-title":"Laboratory Investigation"},{"key":"e_1_2_5_8_2","first-page":"350","article-title":"Hyperelastosis cutis in 2 horses","volume":"2","author":"Lerner D.J.","year":"1978","journal-title":"Journal of Equine Medicine and Surgery"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1984.tb02014.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650410041013"},{"key":"e_1_2_5_11_2","first-page":"146","volume-title":"Manual of Equine Dermatology","author":"Pascoe R.R.R.","year":"1999"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2000.00227.x"},{"key":"e_1_2_5_13_2","first-page":"2365","article-title":"Microscopic anatomy of the skin of the horse","volume":"33","author":"Talukdar A.H.","year":"1972","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1982.3"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-104"},{"key":"e_1_2_5_16_2","unstructured":"Holbrook K.A. 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Pinnell S.R.The structure and function of dermal connective tissue in normal individuals and patients with inherited connective tissue disorders.Scanning Electron Microscopy1982; (Part 4):1731\u201344."}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.0959-4493.2001.00256.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.0959-4493.2001.00256.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1046\/j.0959-4493.2001.00256.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.0959-4493.2001.00256.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T13:59:36Z","timestamp":1693317576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.0959-4493.2001.00256.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1046\/j.0959-4493.2001.00256.x"],"URL":"https:\/\/doi.org\/10.1046\/j.0959-4493.2001.00256.x","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]},"assertion":[{"value":"2001-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}