{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:29:28Z","timestamp":1793986168119,"version":"4.8.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,12,12]],"date-time":"2002-12-12T00:00:00Z","timestamp":1039651200000},"content-version":"vor","delay-in-days":437,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish reference ranges during human pregnancy for normal fetal corpus callosum dimensions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>In a prospective, cross\u2010sectional study of 258 fetuses between 16 and 37 weeks of gestation, measurements of the length, width, and thickness at the level of the anterior mid\u2010body of the corpus callosum were performed, using high\u2010resolution, transvaginal and transabdominal transducers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean length of the corpus callosum was 27.2 (standard deviation, 1.2; 95% confidence interval, 26.02\u201328.37) mm. Width and thickness of the corpus callosum were 5.6 (standard deviation, 1.6; 95% confidence interval, 5.41\u20135.82) mm and 1.9 (standard deviation, 0.7; 95% confidence interval, 1.87\u20132.06) mm, respectively. The size of the corpus callosum as a function of gestational age was expressed by regression equations: length (mm) = \u221220.40 + 1.92 \u00d7 gestational age; width (mm) = \u22120.052 + 0.225 \u00d7 gestational age; thickness (mm) = \u22120.174 + 0.085 \u00d7 gestational age. The dimension\u2013gestational age correlation coefficients were:<jats:italic>r<\/jats:italic>= 0.779 for length,<jats:italic>r<\/jats:italic> = 0.676 for width and<jats:italic>r<\/jats:italic> = 0.494 for thickness; these were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.01). The maximum increase in thickness and width of the corpus callosum occurred between 19 and 21 weeks' gestation, while its length followed a constant growth rate. The normal mean length, width and thickness of the corpus callosum per week, and the 95% confidence limits, were defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study offers normative measurements of the fetal corpus callosum and may facilitate a more objective diagnosis of its congenital abnormalities. Copyright \u00a9 2001 International Society of Ultrasound in Obstetrics and Gynecology<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.0960-7692.2001.00512.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T23:18:35Z","timestamp":1047511115000},"page":"343-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["Development of the human fetal corpus callosum: a high\u2010resolution, cross\u2010sectional sonographic study"],"prefix":"10.1002","volume":"18","author":[{"given":"R.","family":"Achiron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Achiron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,12,12]]},"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.0960-7692.2001.00512.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.0960-7692.2001.00512.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.0960-7692.2001.00512.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T14:51:08Z","timestamp":1700405468000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1046\/j.0960-7692.2001.00512.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["10.1046\/j.0960-7692.2001.00512.x"],"URL":"https:\/\/doi.org\/10.1046\/j.0960-7692.2001.00512.x","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10]]},"assertion":[{"value":"2000-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}