{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:45:14Z","timestamp":1773078314472,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2003,12,16]],"date-time":"2003-12-16T00:00:00Z","timestamp":1071532800000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>Natural killer\/T\u2010cell lymphoma (NKTL) and peripheral T\u2010cell lymphomas (PTCL) are prevalent in the Asian population and exhibit a high association with the Epstein\u2013Barr virus (EBV). Moreover, differentiation of these two groups is often difficult and problematic. We investigated 35 cases of NKTL (22 nasal cases and 13 extranasal cases) and 30 cases of PTCL in terms of their clinical features, immunohistology, EBV positivity, EBV strain\u2010type polymorphism and latent membrane protein 1 (LMP1) deletion variant distribution. Eighteen cases (82%) of nasal NKTL and seven (54%) of extranasal NKTL showed EBV positivity by EBV <jats:italic>in\u2003situ<\/jats:italic> hybridization. Fifteen cases (50%) of PTCL revealed EBV positivity. EBV strain type A was predominant in NKTL (18:5), and EBV strain types A and B were distributed evenly in PTCL (6:6). EBV\u2010positive patients had significantly shorter survival than EBV\u2010negative patients (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), and EBV positivity correlated with advanced clinical stage (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Patients harboring type A EBV showed slightly poorer prognoses than those having type B, though it was not obviously statistically different (<jats:italic>P<\/jats:italic>\u2003=\u20030.07). The LMP1 deletion variant was prevalent in both NKTL (three wild\u2010type LMP1, 15 deletion variants) and PTCL (three wild\u2010type LMP1, eight deletion variants, two coexistent forms) patients, but did not have prognostic impact. Our results indicate that EBV acts as a negative prognostic factor in NKTL and PTCL, and that the intrinsic properties of a specific viral strain might influence the clinical behavior of these diseases.<\/jats:p>","DOI":"10.1046\/j.1320-5463.2003.01552.x","type":"journal-article","created":{"date-parts":[[2003,12,16]],"date-time":"2003-12-16T14:45:40Z","timestamp":1071585940000},"page":"735-743","source":"Crossref","is-referenced-by-count":24,"title":["Comparative analysis of NK\/T\u2010cell lymphoma and peripheral T\u2010cell lymphoma in Korea: Clinicopathological correlations and analysis of EBV strain type and 30\u2010bp deletion variant LMP1"],"prefix":"10.1111","volume":"53","author":[{"given":"Ji Eun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young A.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon 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