{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:26:28Z","timestamp":1761560788498},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,8,6]],"date-time":"2009-08-06T00:00:00Z","timestamp":1249516800000},"content-version":"vor","delay-in-days":2501,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2002,10]]},"abstract":"Abstract<\/jats:title> \n Objective:<\/jats:bold>\n <\/jats:italic>\u2002To evaluate the sonographic characteristics of the fetuses with trisomy\u200318 at 16\u201322 weeks of gestation.<\/jats:p> \n Methods:<\/jats:bold>\n <\/jats:italic>\u2002The subjects were recruited from pregnant women undergoing prenatal sonographic examinations at 16\u201322 weeks of gestation and subsequently proven to be trisomy\u200318. The results of ultrasound findings were retrospectively reviewed in 25 cases with chromosomes which were confirmed as trisomy\u200318.<\/jats:p> \n Results:<\/jats:bold>\n <\/jats:italic>\u2002All cases had at least one abnormal sonographic finding. There was only one case that had no structural abnormality, but fetal growth restriction was documented. The common sonographic findings included fetal growth restriction, choroid plexus cysts, cardiac anomalies, clenched hand, omphalocele and cleft lip. Fetal growth restriction was the most common finding demonstrated in nearly half of all cases. Other less common findings were diaphragmatic hernia, abnormal head shape, polyhydramnios, single umbilical artery.<\/jats:p> \n Conclusion:<\/jats:bold>\n <\/jats:italic>\u2002Nearly all fetuses with trisomy\u200318 had characteristic sonographic patterns of abnormalities demonstrated at midpregnancy. Detailed ultrasound at midpregnancy could effectively screen fetuses with trisomy\u200318 for further genetic testing.<\/jats:p>","DOI":"10.1046\/j.1341-8076.2002.00053.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T07:38:33Z","timestamp":1047454713000},"page":"245-250","source":"Crossref","is-referenced-by-count":29,"title":["Sonographic features of trisomy 18 at midpregnancy"],"prefix":"10.1111","volume":"28","author":[{"given":"Theera","family":"Tongsong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supatra","family":"Sirichotiyakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanane","family":"Wanapirak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pharuhas","family":"Chanprapaph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)90675-9"},{"key":"e_1_2_5_3_2","first-page":"14","volume-title":"Smith's Recognizable Patterns of Human Malformation","author":"Jones KL","year":"1997"},{"key":"e_1_2_5_4_2","first-page":"110","article-title":"Chromosome abnormalities and spontaneous fetal death following amniocentesis: Further data and associations with maternal age","volume":"35","author":"Hook EB","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1399-0004.1985.tb00184.x","article-title":"Survival in trisomy 18. 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