{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:35:37Z","timestamp":1771626937015,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":723,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica Scandinavica"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>Cyclooxygenase\u20102 (COX\u20102) expression in rat kidney is localized to the macula densa and the immediately proximal cTALH and increases after salt restriction. Either ACE inhibitors or AT<jats:sub>1<\/jats:sub> receptor blockers increase COX\u20102 expression in both control and salt\u2010restricted animals, suggesting that the RAS activation feedback inhibits renal cortical COX\u20102 expression. To determine whether increased COX\u20102 expression in response to ACE inhibition mediated increases in renin production, rats were treated with Captopril for 1\u2003week with or without the specific COX\u20102 inhibitor, SC58236. Plasma renin activity increased significantly in the Captopril group. This increase was partially reversed by simultaneous treatment with SC58236. Kidney renin activity also increased in the Captopril group compared with control, which was also significantly inhibited by SC58236 treatment. Because of the localization of bNOS to MD and surrounding cTALH, the current study investigated the role of NO in the regulation of COX\u20102 expression. Rats were fed a normal diet, low salt diet or low salt diet combined with captopril and half of them were treated with the neuronal NOS inhibitor, 7\u2010NI, and half with vehicle. After 7\u2003days, mRNA was extracted and the microsome proteins purified from renal cortex. COX\u20102 mRNA expression was measured by Northern\u2010blot and normalized with GAPDH. 7\u2010NI treatment decreased COX\u20102 mRNA and immunoreactive COX\u20102 expression in each group. In summary, these studies indicate that COX\u20102 from macula densa\/cTALH is a regulator of renin production and release. Angiotensin II may be a negative regulator of cTALH\/macula densa COX\u20102 expression, and NO may mediate increased renal cortical COX\u20102 expression seen in volume depletion. These studies suggest important interactions between the NO and COX\u20102 systems in the regulation of arteriolar tone and the renin\u2013angiotensin system by the macula densa.<\/jats:p>","DOI":"10.1046\/j.1365-201x.2000.00642.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:30:56Z","timestamp":1047353456000},"page":"47-51","source":"Crossref","is-referenced-by-count":28,"title":["Interactions of the renin\u2013angiotensin system and neuronal nitric oxide synthase in regulation of cyclooxygenase\u20102 in the macula densa"],"prefix":"10.1046","volume":"168","author":[{"family":"Harris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"McKanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_3_2_2","first-page":"R1359","article-title":"Macula densa stimulation of renin is reversed by selective inhibition of neuronal nitric oxide synthase","volume":"272","author":"Beierwaltes W.H.","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.2_Suppl.II68"},{"key":"e_1_2_3_4_2","first-page":"410A","article-title":"Nitric oxide upregulates cyclooxygenase\u20102 expression in cTALH","volume":"9","author":"Cheng H.\u2010F.","year":"1998","journal-title":"J A S N"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5505"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.5.1412"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1601"},{"key":"e_1_2_3_8_2","first-page":"F537","article-title":"Prostaglandins in renin release during sodium deprivation","volume":"243","author":"Francisco L.J.","year":"1982","journal-title":"Am J Physiol"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90092-4"},{"key":"e_1_2_3_10_2","first-page":"F948","article-title":"Effect of nitric oxide on renin secretion. 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