{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:33:43Z","timestamp":1770078823914,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":723,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica Scandinavica"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>The present study addresses the question of the relevance of salt intake on jejunal dopamine, Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>\u2010ATPase activity and electrolyte transport. Low salt, but not high salt, intake for 2\u2003weeks increased dopamine levels in the jejunal mucosa accompanied by a marked decrease in \n\t\t\t\t\t<jats:sc>L<\/jats:sc>\u20103,4\u2010dihydroxyphenylalanine tissue levels. By contrast, in rats fasted for 72\u2003h the effect of refeeding for 24\u2003h with a low salt diet failed to change dopamine tissue levels, although it significantly increased those of \n\t\t\t\t\t<jats:sc>L<\/jats:sc>\u20103,4\u2010dihydroxyphenylalanine. By contrast, high salt intake markedly increased the tissue levels of both dopamine and \n\t\t\t\t\t<jats:sc>L<\/jats:sc>\u20103,4\u2010dihydroxyphenylalanine, without changes in dopamine\/\n\t\t\t\t\t<jats:sc>L<\/jats:sc>\u20103,4\u2010dihydroxyphenylalanine tissue ratios. Tissue levels of both \n\t\t\t\t\t<jats:sc>L<\/jats:sc>\u20103,4\u2010dihydroxyphenylalanine and dopamine in control conditions (normal salt intake for 2\u2003weeks) were markedly higher (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) than in rats submitted to 72\u2003h fasting plus 24\u2003h refeeding. The effect of fasting for 72\u2003h followed by 24\u2003h refeeding was a marked decrease in jejunal Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>\u2010ATPase activity, particularly evident for rats fed a normal salt and high salt diets during the refeeding period. Basal short circuit current was similar in rats fed a normal salt diet for 2\u2003weeks and 24\u2003h, and the type of diet failed to alter basal short circuit current after refeeding with normal, low and high salt diets. On the other hand, the effect of prolonged low salt intake was a marked decrease in jejunal Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>\u2010ATPase activity and basal short circuit current, whereas high salt intake failed to alter enzyme activity and basal short circuit current. In rats fed for 2\u2003weeks a high salt diet ouabain was found to be more potent in reducing jejunal short circuit current than in rats fed normal and low salt diets. The effect of furosemide was more marked in rats fed for 2\u2003weeks high and low salt diets than in animals receiving a normal salt intake. Dopamine (up to 1\u2003\u03bcmol\u2003L<jats:sup>\u20131<\/jats:sup>) was found not to alter Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>\u2010ATPase and basal short circuit current in jejunal epithelial sheets, in rats fed with normal, low and high salt diets for 2\u2003weeks and 24\u2003h.<\/jats:p>","DOI":"10.1046\/j.1365-201x.2000.00656.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:30:56Z","timestamp":1047353456000},"page":"225-231","source":"Crossref","is-referenced-by-count":13,"title":["Effect of salt intake on jejunal dopamine, Na<sup>+<\/sup>,K<sup>+<\/sup>\u2010ATPase activity and electrolyte transport"],"prefix":"10.1046","volume":"168","author":[{"family":"Lucas\u2010Teixeira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Serr\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Soares\u2010Da\u2010Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"F795","article-title":"Proximal tubule Na+\u2013K+\u2010ATPase activity is inhibited during high\u2010salt diet: evidence for DA\u2010mediated effect","volume":"254","author":"Bertorello A.","year":"1988","journal-title":"Am J Physiol"},{"key":"e_1_2_6_3_2","first-page":"11","article-title":"The intestinal mucosa as a source of dopamine","volume":"88","author":"Bertorello A.M.","year":"1993","journal-title":"Adv Biosciences"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_5_2","first-page":"R156","article-title":"Fasting alters basal and stimulated ion transport in piglet jejunum","volume":"267","author":"Carey H.V.","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90114-7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.2.187"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199609000-00012"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(89)90186-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.18.6.709"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0840357"},{"key":"e_1_2_6_12_2","first-page":"A1012","article-title":"Effect of food intake on the response of jejunal Na+,K+\u2010ATPase to dopamine","volume":"13","author":"Lucas\u2010Teixeira V.","year":"1999","journal-title":"Faseb J"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1139\/y80-106"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(69)90010-8"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00866320"},{"key":"e_1_2_6_16_2","first-page":"F52","article-title":"Influence of Na+ intake on dopamine\u2010induced inhibition of renal cortical Na+\u2013K+\u2010ATPase","volume":"258","author":"Seri I.","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5379.898"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1993.tb00237.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(98)00500-7"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641969709080803"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.275.6.G1317"}],"container-title":["Acta Physiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-201x.2000.00656.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-201x.2000.00656.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T10:01:53Z","timestamp":1698573713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-201x.2000.00656.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1046\/j.1365-201x.2000.00656.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-201x.2000.00656.x","archive":["Portico"],"relation":{},"ISSN":["0001-6772","1365-201X"],"issn-type":[{"value":"0001-6772","type":"print"},{"value":"1365-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}