{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:49:04Z","timestamp":1791107344398,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":2789,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica Scandinavica"],"published-print":{"date-parts":[[2001,2,19]]},"abstract":"<jats:p>The N\u2010terminal proatrial natriuretic peptide (proANP) has become an important parameter for assessing the prognosis of patients with cardiac disease. Its use for evaluating the hydration status in patients with chronic renal failure, however, is still under investigation. The present study comprised 12 haemodialysis (HD) and 17 pre\u2010dialysis patients. In the HD patients, the inferior vena cava diameter during quiet expiration (IVCe) was estimated by ultrasonography and plasma concentrations of N\u2010terminal proANP, atrial natriuretic peptide (ANP) and cyclic guanosine monophosphate (cGMP) were measured before and 4\u2003h after termination of HD. In the pre\u2010dialysis patients venous blood samples were taken during rest to measure plasma N\u2010terminal proANP and ANP and serum creatinine. Normal values for N\u2010terminal proANP and ANP were obtained from 18 healthy volunteers. The plasma concentrations of N\u2010terminal proANP and ANP in healthy volunteers were 328\u2003\u00b1\u200392 and 11.4.0\u2003\u00b1\u20033.1\u2003p <jats:sc>M<\/jats:sc>\u2003L<jats:sup>\u22121<\/jats:sup>, respectively. In pre\u2010dialysis patients, serum creatinine ranged from 110 to 447\u2003\u03bc<jats:sc>M<\/jats:sc>\u2003L<jats:sup>\u22121<\/jats:sup> and was significantly correlated to plasma N\u2010terminal proANP (<jats:italic>r<\/jats:italic>=0.60, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) but not to ANP. This may indicate that N\u2010terminal proANP is more dependent on renal function for its clearance than ANP, which is probably cleared by extrarenal mechanisms as well. In HD patients, IVCe was significantly correlated to the three hormones before HD, most strongly to N\u2010terminal proANP. After dialysis, IVCe was significantly correlated to ANP and cGMP but was not correlated to N\u2010terminal proANP. This may suggest that proANP takes a longer time than other hormones to reflect changes in intravascular volume. In conclusion, N\u2010terminal proANP is a hormone closely related to degree of renal function. Furthermore, it is a sensitive marker reflecting the interdialytic hydration status in HD patients, as indicated by its high correlation to IVCe, a standard method which is used frequently nowadays to assess the body hydration. However N\u2010terminal proANP could not reflect the acute changes in fluid volume induced by HD, probably because it is slowly metabolized.<\/jats:p>","DOI":"10.1046\/j.1365-201x.2001.00792.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:32:44Z","timestamp":1047353564000},"page":"117-122","source":"Crossref","is-referenced-by-count":16,"title":["Fluid balance in patients with chronic renal failure assessed with N\u2010terminal proatrial natriuretic peptide, atrial natriuretic peptide and 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