{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:05:47Z","timestamp":1792058747875,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":692,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>The risk of colorectal cancer (CRC) in ulcerative colitis (UC) increases with extent and duration of disease. Identifying other risk factors would allow targeting of sub\u2010groups at greatest risk, enabling more cost\u2010effective surveillance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We conducted a case\u2010control study comparing 102 cases of CRC in UC with matched controls. Odds ratios (OR) for cancer risk were estimated by conditional logistic regression. A multivariate model assessed the contribution of individual variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Regular 5\u2010aminosalicylic acid (5\u2010ASA) therapy reduces cancer risk by 75% (OR 0.25, 95% CI: 0.13\u20130.48, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.00001). Adjusting for other variables, taking mesalazine regularly reduces risk by 81% (OR 0.19, 95% CI: 0.06\u20130.61, <jats:italic>P<\/jats:italic>=0.006) and visiting a hospital doctor more than twice a year also reduces risk (OR 0.16, 95% CI: 0.04\u20130.60, <jats:italic>P<\/jats:italic>=0.007). Considering variables independently, having a family history of sporadic CRC in any relative increases risk fivefold (OR 5.0, 95% CI: 1.10\u201322.82, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>CRC risk among UC patients can be reduced by regular therapy with 5\u2010ASA medication. Colonoscopic surveillance may be best targeted on those unable to take 5\u2010ASAs (e.g. due to allergy) and those with a positive family history of CRC.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2036.2000.00698.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:40:52Z","timestamp":1047354052000},"page":"145-153","source":"Crossref","is-referenced-by-count":446,"title":["Colorectal cancer prevention in ulcerative colitis: a case\u2010control 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