{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:14:04Z","timestamp":1753888444709},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":602,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> <jats:italic>Helicobacter pylori<\/jats:italic> infection and associated peptic ulcer disease (PUD) has become less common in some countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim:<\/jats:title><jats:p>To determine if <jats:italic>H.\u200apylori<\/jats:italic> serology alone or combined with a history of ingestion of non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) and an age threshold can be used as an indirect ulcer test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Two hundred and fifty\u2010two consecutive Australian patients (121 males, mean age 52\u2003years) referred for endoscopy were enrolled. Blood was tested by a validated ELISA. At endoscopy, eight biopsies were taken for CLO\u2010testing, culture and histology. NSAID use over the prior 3\u2003months was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>One hundred and six (42%) patients were seropositive for <jats:italic>H. pylori<\/jats:italic>, 48 (19%) patients had PUD and 30 (12%) used NSAIDs. Serology alone had a sensitivity of 52% and a specificity of 60% for identifying PUD; the sensitivity and specificity were 60% and 55%, respectively, when combined with a history of NSAID use. Serology, regardless of NSAID use, would have saved 23% in endoscopy workload but would have missed 17% of PUD cases if an age threshold of &lt;\u200345\u2003years was chosen for omitting endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Serology was a poor ulcer test despite an excellent performance for detecting <jats:italic>H. pylori<\/jats:italic>. A strategy combining serology and an age threshold with a history of NSAID use to reduce endoscopy workloads may not always be appropriate.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2036.2000.00720.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:41:28Z","timestamp":1047354088000},"page":"615-624","source":"Crossref","is-referenced-by-count":19,"title":["Can <i>Helicobacter pylori<\/i> serology still be applied as a surrogate marker to identify peptic ulcer disease in dyspepsia?"],"prefix":"10.1111","volume":"14","author":[{"family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Kalantar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Talley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90599-1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409094856"},{"key":"e_1_2_6_4_2","first-page":"3","article-title":"Temporal trends and geographical variations of peptic ulcer disease","volume":"9","author":"Sonnenberg A.","year":"1995","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1991.tb142171.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7092.1430"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509090281"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.1994.03520010077036","article-title":"Helicobacter pylori in peptic ulcer disease","volume":"272","author":"Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease","year":"1994","journal-title":"J Am Med Assoc"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91545-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91301-P"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309098288"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90085-4"},{"key":"e_1_2_6_13_2","first-page":"991","article-title":"Screening for Helicobacter pylori antibody could reduce endoscopy workload in young dyspeptic patients","volume":"4","author":"Collins JSA","year":"1992","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_6_14_2","first-page":"713","article-title":"Role of Helicobacter pylori serology in screening prior to endoscopy","volume":"4","author":"Mendall MA","year":"1992","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.829.809"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6983.853"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.1.8"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70541-4"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-1746.1998.tb00537.x","article-title":"Helicobacter pylori Consensus. Report of the 1997 Asia Pacific Consensus Conference on the management of Helicobacter pylori infection","volume":"13","author":"Lam SK","year":"1998","journal-title":"J Gastroenterol Hepatol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1001\/archinte.1995.00430090057007","article-title":"Costs of duodenal ulcer therapy with antibiotics","volume":"155","author":"Sonnenberg A","year":"1995","journal-title":"Arch Intern Med"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7042.1321"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812243392602"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7187.833"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812243392601"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199712000-00006"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.9.1167"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1995.tb00782.x"},{"key":"e_1_2_6_28_2","first-page":"S79","article-title":"Intestinal metaplasia","volume":"6","author":"Sipponen P","year":"1994","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.5.8.959"},{"key":"e_1_2_6_30_2","first-page":"1403","article-title":"Helicobacter pylori\u2010negative gastric ulcer","volume":"87","author":"Borody TJ","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_31_2","first-page":"1398","article-title":"Non\u2010steroidal anti\u2010inflammatory drug\u2010associated gastric ulcers do not require Helicobacter pylori for their development","volume":"87","author":"Laine L","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000201350"},{"key":"e_1_2_6_33_2","first-page":"1154","article-title":"Helicobacter pylori\u2010negative duodenal ulcer","volume":"86","author":"Borody TJ","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90067-8"},{"key":"e_1_2_6_35_2","doi-asserted-by":"crossref","unstructured":"TalleyNJ.IsHelicobacter pylorinegative duodenal ulcer a separate disease?In: Malfertheiner P Ditschuneit H eds.Helicobacter Pylori Gastritis and Peptic Ulcer. Berlin: Springer\u2010Verlag 1990: 340\u20134.","DOI":"10.1007\/978-3-642-75315-2_49"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(99)00101-7"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00568.x"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_6_39_2","first-page":"2125","article-title":"Diagnostic tests for Helicobacter pylori: a prospective evaluation of their accuracy","volume":"91","author":"Thijs JC","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004057"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91899-6"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90929-4"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92340-3"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.302"},{"key":"e_1_2_6_45_2","first-page":"95","article-title":"Diagnostic tests for Helicobacter pylori\u2014can they help select patients for endoscopy?","volume":"109","author":"Fraser AG","year":"1996","journal-title":"NZ Med J"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00215.x"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026683026028"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9041228"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2036.2000.00720.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2036.2000.00720.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2036.2000.00720.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T17:11:07Z","timestamp":1698599467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2036.2000.00720.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1046\/j.1365-2036.2000.00720.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2036.2000.00720.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}