{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T01:28:59Z","timestamp":1699925339243},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":632,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>The cost\u2010effectiveness of determining <jats:italic>Helicobacter pylori<\/jats:italic> status after treatment remains to be established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim:<\/jats:title><jats:p>To determine the benefit of post\u2010treatment assessment of <jats:italic>H. pylori<\/jats:italic> eradication in patients with uncomplicated duodenal ulcer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods:<\/jats:title><jats:p>A decision analysis was performed in patients with uncomplicated duodenal ulcer who were <jats:italic>H. pylori<\/jats:italic>\u2010positive and had received eradication therapy. A decision tree was devised to compare the costs per patient of two different strategies: (a) systematic performance of post\u2010treatment urea breath test and new treatment if positive; and (b) clinical follow\u2010up, <jats:sup>13<\/jats:sup>C\u2010urea breath test if dyspeptic symptoms recurred and eradication treatment if the test was positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Post\u2010eradication <jats:sup>13<\/jats:sup>C\u2010urea breath test was notably more expensive than clinical follow\u2010up, both in a low\u2010cost per care setting (197 vs. 132\u2003Euros) and in a high\u2010cost per care (614 vs. 340\u2003US\u2003$) scenario. This conclusion remained stable for a wide range of variations of the variables included in the decision tree (e.g. cure rates of eradication treatment, cost of the urea breath test or sensitivity, and specificity of urea breath test to detect eradication).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>In patients with uncomplicated duodenal ulcer, evaluation of eradication after <jats:italic>H. pylori<\/jats:italic> treatment markedly increases costs with no clear improvement in results and therefore should not be performed routinely.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2036.2000.00735.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:41:05Z","timestamp":1047354065000},"page":"433-442","source":"Crossref","is-referenced-by-count":13,"title":["Diagnosis of <i>Helicobacter pylori<\/i> after triple therapy in uncomplicated duodenal ulcers\u2014a cost\u2010effectiveness 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