{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:15:41Z","timestamp":1790417741013,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":602,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Benzodiazepines are used as sedatives for some intestinal procedures and as hypnotics, and this is the reason for studying their effects on duodenojejunal motility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Antroduodenojejunal manometry was performed in 13 healthy volunteers on two different occasions, when placebo or midazolam were given intravenously (randomized, double\u2010blind). A bolus dose of midazolam 0.03\u2003mg\/kg was followed by 0.015\u2003mg\/kg after 1.5, 3 and 4.5\u2003h. After 5\u2003h observation of interdigestive motility, the volunteers were given a test meal and recording continued for another hour. Twenty\u2010eight motility variables were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>With midazolam the median motility index of phase III in the proximal duodenum was increased by 37% (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), which was a consequence of both a longer duration (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) and higher pressure amplitudes (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), compared with placebo. A longer duration (9%) of phase III was also seen in the distal duodenum (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). With midazolam the duration of the migrating motor complex was shortened by 27% (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). No statistically significant difference was found for the number of episodes of phase III registered (<jats:italic>P<\/jats:italic>=0.09), or for the other 22 motility variables compared including the duodenal retroperistalsis in late phase III.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Midazolam does affect some aspects of duodenal motility, especially in the proximal part, but phase III\u2010related retroperistalsis is not affected.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2036.2000.00741.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:41:28Z","timestamp":1047354088000},"page":"571-577","source":"Crossref","is-referenced-by-count":27,"title":["Effects of midazolam on small bowel motility in humans"],"prefix":"10.1111","volume":"14","author":[{"family":"Castedal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Bj\u00f6rnsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Abrahamsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/55.4.289"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/55.11.1095"},{"key":"e_1_2_6_4_2","first-page":"283","article-title":"Midazolam for upper gastrointestinal endoscopy","volume":"66","author":"Kawar P","year":"1984","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010345"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010344"},{"key":"e_1_2_6_7_2","first-page":"860","article-title":"Effect of intravenous midazolam on esophageal motility testing in normal volunteers","volume":"88","author":"Marsh JK","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199207000-00013"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70155-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1995.tb09857.x"},{"key":"e_1_2_6_11_2","first-page":"G113","article-title":"Mechanisms behind changes in gastric acid and bicarbonate outputs during the human interdigestive motility cycle","volume":"270","author":"Dalenb\u00e4ck JF","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018835806251"},{"key":"e_1_2_6_13_2","first-page":"A708","article-title":"Scintigraphic assessment of interdigestive duodenogastric reflux in humans. Discrimination between duodenal and biliary refluxate","volume":"112","author":"Castedal M","year":"1997","journal-title":"Gastroenterology"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90573-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90620-2"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90335-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90696-7"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90525-2"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1994.tb00197.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90763-7"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(98)00071-5"},{"key":"e_1_2_6_22_2","first-page":"247","article-title":"Mechanisms for central vagal control of lower esophageal sphincter relaxation","volume":"11","author":"Abrahams TP","year":"1999","journal-title":"Neurogastroenterol Mot"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90504-W"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.85.305"},{"key":"e_1_2_6_25_2","unstructured":"ChristensenJ.The enteric nervous system. In: Kumar D Wingate D eds. An Illustrated Guide to Gastrointestinal Motility 2nd edn. London: Churchill Communications Europe 1993: 10\u201331."}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2036.2000.00741.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2036.2000.00741.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2036.2000.00741.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T17:11:20Z","timestamp":1698599480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2036.2000.00741.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1046\/j.1365-2036.2000.00741.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2036.2000.00741.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}