{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T23:11:38Z","timestamp":1794697898669,"version":"4.9.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":602,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Normalization of oesophageal acid exposure using high dose proton pump inhibitors in patients who are candidates for ablation therapy has been suggested to be essential for successful Barrett's reversal. However, the success rate for achieving pH normalization has not been determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Patients with Barrett's oesophagus (2\u20136\u2003cm in length) who were found to be eligible for ablation therapy using multipolar electrocoagulation were included in this prospective study. Patients underwent an upper endoscopy to determine Barrett's length and other anatomic characteristics. Biopsies were obtained to rule out dysplasia. Subsequently, patients were treated with omeprazole 40\u2003mg b.d. Twenty\u2010four hour oesophageal pH monitoring was performed after a mean period of 8.4\u2003\u00b1\u20030.6\u2003days of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Twenty\u2010five patients were enrolled into the study. The pH test was abnormal in four (16%) of the study subjects. An additional two (8%) patients had abnormal supine percentage time with pH less than 4. There was no significant difference in oesophageal acid control between patients with long vs. short segment Barrett's oesophagus. Elderly (&gt;\u200360\u2003years) patients tended to have less acid control than younger (\u2264\u200360\u2003years) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Failure of oesophageal acid control in candidates for Barrett's oesophagus reversal on very high dose of proton pump inhibitor is not uncommon. Our study suggests that ambulatory 24\u2010h oesophageal pH monitoring should be considered in all candidates for Barrett's reversal who are treated with high dose proton pump inhibitor to ensure normalization of oesophageal acid exposure.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2036.2000.00749.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:41:28Z","timestamp":1047354088000},"page":"597-602","source":"Crossref","is-referenced-by-count":77,"title":["Failure of oesophageal acid control in candidates for Barrett's oesophagus reversal on a very high dose of proton pump inhibitor"],"prefix":"10.1111","volume":"14","author":[{"family":"Fass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sampliner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Malagon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Wendel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Garewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608073150605"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90420-H"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0142(19981115)83:10<2049::aid-cncr1>3.3.co;2-u"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307557"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90646-T"},{"key":"e_1_2_6_7_2","first-page":"A537","article-title":"Regression of columnar\u2010lined esophagus following KTP laser ablation with acid suppression","volume":"110","author":"Jones R","year":"1996","journal-title":"Gastroenterology"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(95)70245-8"},{"key":"e_1_2_6_9_2","first-page":"A290","article-title":"Photodynamic therapy in the treatment of Barrett's esophagus","volume":"110","author":"Wang KK","year":"1996","journal-title":"Gastroenterology"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(93)70017-6"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(95)70246-6"},{"key":"e_1_2_6_12_2","first-page":"1719","article-title":"Photodynamic therapy for Barrett's esophagus: clinical update","volume":"91","author":"Overholt BF","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(96)03054-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70004-4"},{"key":"e_1_2_6_15_2","first-page":"1554","article-title":"P9 bicap cautery converts Barrett's epithelium to squamous mucosa","volume":"90","author":"Aronchick CA","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018850824287"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01538064"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90285-9"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307581"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088563"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(92)70536-7"},{"key":"e_1_2_6_22_2","article-title":"Repeat laser therapy of recurrent Barrett's esophagus: success with anacidity","volume":"3","author":"Brandt L","year":"1994","journal-title":"Gastrointest Endosc"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.525_b.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(97)80188-5"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70380-9"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.6.747"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70322-8"},{"key":"e_1_2_6_28_2","first-page":"G1339","article-title":"Ablation of Barrett's epithelium by endoscopic argon plasma coagulation used in combination with high dose omeprazole","volume":"116","author":"Schulz H","year":"1999","journal-title":"Gastroenterology"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1572-0241.1998.00362.x","article-title":"Practice parameters committee of the ACG. 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