{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:08:34Z","timestamp":1787004514405,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":821,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Functional dyspepsia is characterized by upper abdominal pain or discomfort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      To assess the benefit of the 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      \u2010receptor antagonist alosetron in a pilot, dose\u2010ranging, placebo\u2010controlled, multicentre, randomized clinical trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 320 functional dyspepsia patients received placebo (\n                      <jats:italic>n<\/jats:italic>\n                      =81), or alosetron 0.5\u2003mg b.d. (\n                      <jats:italic>n<\/jats:italic>\n                      =77), 1.0\u2003mg b.d. (\n                      <jats:italic>n<\/jats:italic>\n                      =79) or 2.0\u2003mg b.d. (\n                      <jats:italic>n<\/jats:italic>\n                      =83) for 12\u2003weeks, followed by 1\u2003week of follow\u2010up. Primary efficacy was the 12\u2010week average rate of adequate relief of upper abdominal pain or discomfort. Secondary endpoints assessed pain and upper gastrointestinal symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twelve\u2010week average rates of adequate relief of pain or discomfort were 46% (95% CI: 37\u201354%), 55% (95% CI: 46\u201363%), 55% (95% CI: 47\u201364%) and 47% (95% CI: 38\u201355%) in the placebo, 0.5\u2003mg, 1.0\u2003mg and 2.0\u2003mg alosetron groups, respectively. Alosetron 0.5\u2003mg or 1.0\u2003mg showed potential benefit over placebo for early satiety and postprandial fullness. Females showed greater responses compared to males. Patients with adequate relief had significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2003&lt;\u20030.001) greater reductions in severity and frequency of functional dyspepsia symptoms than those without adequate relief. Constipation was the most commonly reported adverse event.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Alosetron showed potential benefit in relieving functional dyspepsia symptoms compared to placebo. Patients with adequate relief of upper abdominal pain or discomfort showed improvements in multiple functional dyspepsia symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1046\/j.1365-2036.2001.00941.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T22:44:03Z","timestamp":1047336243000},"page":"525-537","source":"Crossref","is-referenced-by-count":97,"title":["A dose\u2010ranging, placebo\u2010controlled, randomized trial of alosetron in patients with functional dyspepsia"],"prefix":"10.1111","volume":"15","author":[{"given":"N. 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