{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:04:02Z","timestamp":1771016642784,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,1,12]],"date-time":"2002-01-12T00:00:00Z","timestamp":1010793600000},"content-version":"vor","delay-in-days":214,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2001,6,12]]},"abstract":"<jats:p>Gastro\u2010oesophageal reflux disease (GERD) is one of the most common conditions presenting to the primary care physician. Despite progress in understanding and treatment of the disease, strategies for capitalizing on these advances are less well developed. In many practices, H<jats:sub>2<\/jats:sub>\u2010receptor antagonists still remain the most widely prescribed treatment for GERD, despite the availability of the more effective acid\u2010suppressant proton pump inhibitors.<\/jats:p><jats:p>This review examines the relative efficacies of acid\u2010suppressant drugs in minimizing oesophageal acid exposure and outlines the evidence for the superiority of proton pump inhibitors over standard\u2010dose H<jats:sub>2<\/jats:sub>\u2010antagonists in symptom relief, erosion healing and prevention of relapse in GERD. Current prescribing patterns and considerations for the general practitioner are also examined. The availability and impact of over\u2010the\u2010counter H<jats:sub>2<\/jats:sub>\u2010antagonists on the treatment of GERD and their relative cost\u2010effectiveness vs. proton pump inhibitors are also addressed.<\/jats:p><jats:p>A hierarchy of drug efficacy (full\u2010dose proton pump inhibitor\u2003&gt;\u2003half\u2010dose proton pump inhibitor\u2003&gt;\u2003high\u2010dose H<jats:sub>2<\/jats:sub>\u2010antagonist\u2003&gt;\u2003standard\u2010dose H<jats:sub>2<\/jats:sub>\u2010antagonist or prokinetic) applies in principle to all GERD patients, (with or without oesophagitis). The most effective initial therapy for GERD is also likely to be the most cost\u2010effective one, if treatment failure leads to higher utilization of medical resources.<\/jats:p><jats:p>The application of these recommendations to the management of non\u2010endoscoped GERD, endoscopy\u2010negative GERD and low\u2010grade oesophagitis as well as higher grade oesophagitis is also reviewed.<\/jats:p>","DOI":"10.1046\/j.1365-2036.2001.00985.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:44:49Z","timestamp":1047354289000},"page":"765-772","source":"Crossref","is-referenced-by-count":26,"title":["Acid suppression in the management of gastro\u2010oesophageal reflux disease\u2014an appraisal of treatment options in primary care"],"prefix":"10.1111","volume":"15","author":[{"given":"R.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bytzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509090292"},{"key":"e_1_2_8_3_2","first-page":"577","article-title":"Critical issues in the management of gastroesophageal reflux disease","volume":"7","author":"Freston JW","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000200917"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90017-S"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800561211"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198606001-00008"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00181.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1995.tb00778.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7146.1720"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537246"},{"key":"e_1_2_8_13_2","first-page":"15","article-title":"Loss of acid suppression during dosing with H2\u2010receptor antagonists","volume":"4","author":"Wilder\u2010Smith CH","year":"1990","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209096000"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00257.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1995.tb00779.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)80627-6"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"e_1_2_8_19_2","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/j.1572-0241.1999.1123_a.x","article-title":"The Practice Parameters Committee of the American College of Gastroenterology. 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