{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:43:53Z","timestamp":1765079033144},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,12,20]],"date-time":"2001-12-20T00:00:00Z","timestamp":1008806400000},"content-version":"vor","delay-in-days":120,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2001,8,22]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>: The relationship between <jats:italic>Helicobacter pylori<\/jats:italic> infection and non\u2010ulcer dyspepsia is not established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>: To determine whether eradication of <jats:italic>H. pylori<\/jats:italic> might be of benefit in non\u2010ulcer dyspepsia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>: We randomly assigned 129 <jats:italic>H. pylori<\/jats:italic> infected patients with severe epigastric pain, without gastro\u2010oesophageal reflux symptoms, to receive twice daily treatment with 300\u2003mg of ranitidine, 1000\u2003mg of amoxicillin, and 500\u2003mg of clarithromycin for 7\u2003days and 124 such patients to receive identical\u2010appearing placebos.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>: Treatment was successful (decrease of symptoms at 12\u2003months) in 62% of patients in the active\u2010treatment group and in 60% of the placebo group (N.S.). At 12\u2003months, the rate of eradication of <jats:italic>H. pylori<\/jats:italic> was 69% in the active\u2010treatment group and 18% in the placebo group (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Complete relief of symptoms occurred significantly more frequently in patients on the active treatment (43%) than in placebo\u2010treated patients (31%, <jats:italic>P<\/jats:italic>=0.048). Within the active\u2010treatment group, therapeutic success was significantly more frequent in the non\u2010infected patients (84% vs. 64%, <jats:italic>P<\/jats:italic>=0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>: Although eradicating <jats:italic>H. pylori<\/jats:italic> is not likely to relieve symptoms in the majority of patients with non\u2010ulcer dyspepsia, a small proportion of <jats:italic>H. pylori<\/jats:italic>\u2010infected patients may benefit from eradication treatment.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2036.2001.01014.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T03:44:56Z","timestamp":1047354296000},"page":"1177-1185","source":"Crossref","is-referenced-by-count":44,"title":["There are some benefits for eradicating <i>Helicobacter pylori<\/i> in patients with non\u2010ulcer dyspepsia"],"prefix":"10.1111","volume":"15","author":[{"given":"S. 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