{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:08:43Z","timestamp":1787004523279,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2001,12,20]],"date-time":"2001-12-20T00:00:00Z","timestamp":1008806400000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2001,9,27]]},"abstract":"\n Background:<\/jats:title>\n An increased permeability to sugars is found in the intestine of untreated patients with coeliac disease after oral ingestion.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n To test whether\n in vitro<\/jats:italic>\n permeability resembles\n in vivo<\/jats:italic>\n permeability tests and whether an\n in vitro<\/jats:italic>\n gliadin gluten challenge could be performed by an\n in vitro<\/jats:italic>\n permeability test.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n We measured\n in vivo<\/jats:italic>\n (urinary excretion after sucrose\u2013lactulose\u2013mannitol ingestion) and\n in vitro<\/jats:italic>\n permeability (by mini\u2010Ussing chambers) in 25 healthy controls, 12 relatives of coeliac disease patients, 19 treated, eight partly treated and 16 untreated patients with coeliac disease.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In vivo<\/jats:italic>\n sugar permeability was increased in nearly all coeliac patients. Additionally,\n in vitro<\/jats:italic>\n permeability to lactulose (\n P<\/jats:italic>\n =0.0007), mannitol (\n P<\/jats:italic>\n =0.004) and sucrose (\n P<\/jats:italic>\n =0.042) was higher in untreated patients with coeliac disease. It correlated with\n in vivo<\/jats:italic>\n permeability (sucrose \u03c4=0.61,\n P<\/jats:italic>\n =0.006; lactulose \u03c4=0.41,\n P<\/jats:italic>\n \u2003<\u20030.0001; mannitol \u03c4=\u2013\u20030.56,\n P<\/jats:italic>\n =0.62) and was dependent on mucosal damage. An\n in vitro<\/jats:italic>\n gliadin challenge over 24\u2003h could not significantly change\n in vitro<\/jats:italic>\n permeability in treated patients with coeliac disease.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n An\n in vitro<\/jats:italic>\n permeability test capable of measuring elevated permeability in coeliac mucosa was described, but this test cannot replace oral gluten challenge by\n in vitro<\/jats:italic>\n gliadin incubation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1046\/j.1365-2036.2001.01034.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T22:45:08Z","timestamp":1047336308000},"page":"1417-1425","source":"Crossref","is-referenced-by-count":15,"title":["In vivo<\/i>\n and\n in vitro<\/i>\n permeability in coeliac disease"],"prefix":"10.1111","volume":"15","author":[{"given":"H.","family":"Vogelsang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schwarzenhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Oberhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016886"},{"key":"e_1_2_7_3_2","first-page":"394","article-title":"Screening for coeliac disease: a prospective study on the value of noninvasive tests","volume":"90","author":"Vogelsang H","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.23.3.202"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199603000-00006"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.11.1515"},{"key":"e_1_2_7_7_2","first-page":"1838","article-title":"Screening for coeliac disease in first\u2010degree relatives of patients with coeliac disease by lactulose\/mannitol test","volume":"90","author":"Vogelsang H","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0016-5085(81)90004-4","article-title":"Gluten sensitivity of small intestinal mucosa in vitro: quantitative assessment of histologic change","volume":"80","author":"Howdle PD","year":"1981","journal-title":"Gastroenterology"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90607-5"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.22.11.939"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613040"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90440-9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088568"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199804000-00010"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0950-3528(95)90032-2"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106108"},{"key":"e_1_2_7_19_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/00365521.1975.12096935","article-title":"In vitro pathogenetic studies of coeliac disease. Effects of protein digests on coeliac intestinal biopsy specimens maintained in culture for 48\u2003hours","volume":"10","author":"Jos J","year":"1975","journal-title":"Scand J Gastroenterol"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(66)90080-5"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197911000-00010"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8698227"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0740427"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199804000-00001"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.6.774"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2036.2001.01034.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2036.2001.01034.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2036.2001.01034.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T11:25:34Z","timestamp":1695813934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2036.2001.01034.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,27]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2001,9,27]]}},"alternative-id":["10.1046\/j.1365-2036.2001.01034.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2036.2001.01034.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9,27]]}}}