{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:10:53Z","timestamp":1761707453215,"version":"3.30.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":3144,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>Chediak\u2013Higashi syndrome in Japanese black cattle is a hereditary disease with prolonged bleeding time and partial albinism. In the present study, we mapped the locus responsible for the disease (<jats:italic>CHS<\/jats:italic>) by linkage analysis using microsatellite genotypes of paternal half\u2010sib pedigrees obtained from commercial herds. Analysis revealed significant linkage between the<jats:italic>CHS<\/jats:italic>locus and marker loci on the proximal end of bovine chromosome 28. The<jats:italic>CHS<\/jats:italic>locus was mapped on the region incorporating the microsatellite markers<jats:italic>BMC6020<\/jats:italic>,<jats:italic>BM2892<\/jats:italic>, and<jats:italic>RM016<\/jats:italic>with recombination fraction 0 and lod score 4 \u00b79\u201311 \u00b72. We also assigned the bovine CHS1\/LYST, the homologue of the gene responsible for human Chediak\u2013Higashi syndrome, to bovine chromosome 28 using a bovine\/murine somatic cell hybrid panel. These findings suggest that a mutation in the CHS1\/LYST gene is likely to be responsible for Chediak\u2013Higashi syndrome in Japanese black cattle.<\/jats:p>","DOI":"10.1046\/j.1365-2052.2000.00607.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T10:55:51Z","timestamp":1047293751000},"page":"87-90","source":"Crossref","is-referenced-by-count":7,"title":["Localization of the locus responsible for Chediak\u2013Higashi syndrome in cattle to bovine chromosome 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