{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:27:19Z","timestamp":1777116439780,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,4,5]],"date-time":"2002-04-05T00:00:00Z","timestamp":1017964800000},"content-version":"vor","delay-in-days":794,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p> <jats:italic>Aims<\/jats:italic>\u2002To investigate the effects of sibutramine in combination with alcohol in a double\u2010blind, randomised, placebo\u2010controlled, four\u2010way crossover study in 20 healthy volunteers.<\/jats:p><jats:p> <jats:italic>Methods\u2002On each study day each volunteer received either: sibutramine 20\u2003mg+0.5\u2003g\u2003kg<jats:sup>\u22121<\/jats:sup> alcohol; sibutramine 20\u2003mg+placebo alcohol; placebo capsules+0.5\u2003g\u2003kg<jats:sup>\u22121<\/jats:sup><\/jats:italic> alcohol; or placebo capsules+placebo alcohol. Alcohol was administered 2\u2003h following ingestion of the study capsules. During each study day, assessments of cognitive performance were made prior to dosing, and at 3, 4.5, 6 and 10\u2003h post dosing. Blood alcohol concentration was estimated using a breath alcometer immediately prior to each cognitive performance test session. Each study day was followed by a minimum 7 day washout period.<\/jats:p><jats:p> <jats:italic>Results\u2002Alcohol was found to produce statistically significant impairments in tests of attention (maximum impairment to speed of digit vigilance=49\u2003ms) and episodic memory (maximum impairment to speed of word recognition=74\u2003ms). Alcohol also increased body sway (maximum increase 17.4 units) and lowered self rated alertness (maximum decrease 13.6\u2003mm). These effects were produced by an inferred blood alcohol level of 53.2\u2003mg\u2003dl<jats:sup>\u22121<\/jats:sup><\/jats:italic>. Sibutramine was not found to potentiate any of the effects of alcohol. There was a small, yet statistically significant, interaction effect observed on the sensitivity index of the picture recognition task. In this test, the combined effects of sibutramine and alcohol were smaller than the impairments produced by alcohol alone. Sibutramine, when dosed alone, was associated with improved performance on several tasks. Sibutramine improved attention (mean speed of digit vigilance improved by 21\u2003ms), picture recognition speed (improvement at 3=81) and motor control (tracking error at 3\u2003h reduced by 1.58\u2003mm). Also sibutramine improved postural stability (reducing body sway at 3\u2003h by 14.2 units). Adverse events reported were unremarkable and consistent with the known pharmacology of sibutramine and alcohol.<\/jats:p><jats:p> <jats:italic>Conclusions<\/jats:italic>\u2002There was little evidence of a clinically relevant interaction of sibutramine with the impairment of cognitive function produced by alcohol in healthy volunteers. The single statistically significant interaction indicated a reduction, rather than a worsening, of alcohol\u2010induced impairment when sibutramine is taken concomitantly. Sibutramine when administered alone is associated with improved performance on several tasks.<\/jats:p>","DOI":"10.1046\/j.1365-2125.2000.00131.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T04:37:22Z","timestamp":1047357442000},"page":"110-117","source":"Crossref","is-referenced-by-count":38,"title":["Effects of sibutramine alone and with alcohol on cognitive function in healthy volunteers"],"prefix":"10.1111","volume":"49","author":[{"given":"K. 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