{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:32:01Z","timestamp":1789500721845,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,2,27]],"date-time":"2002-02-27T00:00:00Z","timestamp":1014768000000},"content-version":"vor","delay-in-days":332,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2001,4]]},"abstract":"\n Aims\u2002<\/jats:bold>\n To examine whether systemic \u03b2\n 2<\/jats:sub>\n \u2010adrenoceptor responses, such as tachycardia, tremor and hypokalaemia, can be used as a surrogate for the 20\u2003min pharmacokinetic profile of inhaled salbutamol.\n <\/jats:p>\n \n Methods\u2002<\/jats:bold>\n A retrospective analysis of eight separate published studies in healthy volunteers was performed, each with an identical protocol evaluating the early lung absorption profile of a nominal 1200\u2003\u00b5g dose of salbutamol given by different inhaler devices. Peak postural finger tremor, plasma potassium and heart rate were assesssed.\n <\/jats:p>\n \n Results\u2002<\/jats:bold>\n We found the maximum (\n C<\/jats:italic>\n max<\/jats:sub>\n ) and average (\n C<\/jats:italic>\n av<\/jats:sub>\n ) plasma concentrations of salbutamol to be correlated (\n P<\/jats:italic>\n \u2003<\u20030.0001) to change in plasma potassium (\n C<\/jats:italic>\n max<\/jats:sub>\n r<\/jats:italic>\n \u2003=\u20030.904;\n C<\/jats:italic>\n av<\/jats:sub>\n r<\/jats:italic>\n \u2003=\u20030.899) and tremor (\n C<\/jats:italic>\n max<\/jats:sub>\n r<\/jats:italic>\n \u2003=\u20030.875;\n C<\/jats:italic>\n av<\/jats:sub>\n r<\/jats:italic>\n \u2003=\u20030.857). No significant correlations existed between change in heart rate and\n C<\/jats:italic>\n max<\/jats:sub>\n (\n r<\/jats:italic>\n \u2003=\u20030.425) or\n C<\/jats:italic>\n av<\/jats:sub>\n (\n r<\/jats:italic>\n \u2003=\u20030.415).\n <\/jats:p>\n \n Conclusions\u2002<\/jats:bold>\n Systemic \u03b2\n 2<\/jats:sub>\n \u2010adrenoceptor responses, in particular hypokalaemia and tremor, but not heart rate, appear to be good surrogates for evaluating the lung delivery of inhaled salbutamol. Consequently it is suggested that potassium or tremor responses may be used to evaluate the relative lung delivery of salbutamol from different inhaler devices.\n <\/jats:p>","DOI":"10.1046\/j.1365-2125.2001.01362.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T23:41:19Z","timestamp":1047339679000},"page":"359-362","source":"Crossref","is-referenced-by-count":25,"title":["Pharmacokinetics and systemic \u03b2\n 2<\/sub>\n \u2010adrenoceptor\u2010mediated responses to inhaled salbutamol"],"prefix":"10.1111","volume":"51","author":[{"given":"Stephen J.","family":"Fowler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Lipworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,2,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.00493.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199732010-00003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.3.325"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.10.981"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10081820"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/pupt.1997.0093"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1996.tb00191.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00648.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00041.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050335"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00558154"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00562546"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.3.546"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1983.tb04982.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.6.658"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.12.1036"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2125.2001.01362.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2125.2001.01362.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2125.2001.01362.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T02:33:05Z","timestamp":1697509985000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2125.2001.01362.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1046\/j.1365-2125.2001.01362.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2125.2001.01362.x","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}