{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:21:48Z","timestamp":1791073308067,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of the present study is to describe any changes in the prevalence of sensitization to common contact allergens in patch-tested patients over a 12-year period. Attention is given to possible effects of preventive strategies introduced in Denmark regarding nickel and chromate sensitization during that period, and particular areas of concern are identified. Members of the Danish Contact Dermatitis Group collected patch-test results from consecutive eczema patients as well as information about exposures and demographic variables over a 6-month period in 1985\u201386. The investigation was repeated in 1997\u201398 in the same clinics, at the same time of year, using identical methods and patch-test substances, including nickel sulphate 5%, potassium dichromate 0\u00b75% and fragrance mix 8%. Nickel was the most common contact allergen in both study periods, followed by the fragrance mix. In children 0\u201318 years of age, the frequency of nickel allergy decreased from 24\u00b78% in the first study period to 9\u00b72% in the second study period (P &amp;lt; 0\u00b70008). Fragrance mix allergy doubled in frequency from 4\u00b71% in 1985\u201386 to 9\u00b79% in 1997\u201398, an increase that affected all age groups. Contact allergy to potassium dichromate decreased significantly from 3\u00b70% in the first period to 1\u00b72% in the second period (P = 0\u00b7001). The decrease was seen in both sexes and was most pronounced among those of working age. No other significant changes were found in the frequency of sensitization to common allergens over the 12-year observation period.<\/jats:p>","DOI":"10.1046\/j.1365-2133.2000.03362.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T05:24:51Z","timestamp":1047360291000},"page":"490-495","source":"Crossref","is-referenced-by-count":171,"title":["Changes in the pattern of sensitization to common contact allergens in Denmark between 1985\u201386 and 1997\u201398, with a special view to the effect of preventive strategies"],"prefix":"10.1093","volume":"142","author":[{"given":"J.duus","family":"Johansen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Christophersen","sequence":"additional","affiliation":[{"name":"The Dermatology Clinic, Geels Plads 20, 2830 Virum, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kaaber","sequence":"additional","affiliation":[{"name":"The Dermatology Clinic, Bredgade 30, 7400 Herning, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Veien","sequence":"additional","affiliation":[{"name":"The Dermatology Clinic, Vesterbro 99, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2023012714354880300_b1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1600-0536.1989.tb04746.x","article-title":"Clinical patch test data evaluated by multivariate analysis.","volume":"21","author":"Christophersen","year":"1989","journal-title":"Contact Dermatitis"},{"key":"2023012714354880300_b2","first-page":"287","article-title":"Terminology of contact dermatitis.","volume":"50","author":"Wilkinson","year":"1970","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"2023012714354880300_b3","first-page":"36","article-title":"Epidemiology of contact dermatitis. 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