{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:08:34Z","timestamp":1787004514751,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 61\u2013year-old woman, who was known to have Hailey\u2013Hailey disease, presented with increasing vulval soreness. Biopsy showed vulval intraepithelial neoplasia (VIN) 3 and subsequent histology from a vulvectomy specimen showed extensive VIN with early invasive squamous cell carcinoma. This may be another example of chronic inflammation of the vulval area leading to the development of squamous cell carcinoma. However, in this case, chronic human papillomavirus may also have played a part, leading to VIN and reactivation of the Hailey\u2013Hailey disease. We can find no previous reports of squamous cell carcinoma developing in the setting of Hailey\u2013Hailey disease.<\/jats:p>","DOI":"10.1046\/j.1365-2133.2000.03374.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T00:24:51Z","timestamp":1047342291000},"page":"540-542","source":"Crossref","is-referenced-by-count":42,"title":["Squamous cell carcinoma arising in Hailey\u2013Hailey disease of the vulva"],"prefix":"10.1093","volume":"142","author":[{"given":"S.E.","family":"Cockayne","sequence":"first","affiliation":[{"name":"Department of Dermatology, Barnsley District General Hospital, Gawber Rd, Barnsley S75 2EP, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Rassl","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northern General Hospital, Herries Rd, Sheffield S5 7AU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.E.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Barnsley District General Hospital, Gawber Rd, Barnsley S75 2EP, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2023012714365889600_b1","first-page":"1844","volume-title":"Textbook of Dermatology","author":"Burge","year":"1998","edition":"6th edn"},{"key":"2023012714365889600_b2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2133.1992.tb00658.x","article-title":"Hailey\u2013Hailey disease: the clinical features, response to treatment and prognosis.","volume":"126","author":"Burge","year":"1992","journal-title":"Br J Dermatol"},{"key":"2023012714365889600_b3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/1523-1747.ep12320741","article-title":"Hailey\u2013Hailey disease maps to a 5 cM interval on chromosome 3q21\u2013q24.","volume":"105","author":"Richard","year":"1995","journal-title":"J Invest Dermatol"},{"key":"2023012714365889600_b4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/1097-0142(196103\/04)14:2<330::AID-CNCR2820140213>3.0.CO;2-1","article-title":"Infiltrative squamous cell (epidermoid) carcinoma of the vulva.","volume":"14","author":"Gosling","year":"1961","journal-title":"Cancer"},{"key":"2023012714365889600_b5","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1471-0528.1990.tb02502.x","article-title":"The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women.","volume":"97","author":"Leibowitz","year":"1990","journal-title":"Br J Obstet Gynaecol"},{"key":"2023012714365889600_b6","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0046-8177(98)90198-8","article-title":"Vulvar lichen sclerosus and squamous cell carcinoma: a cohort, case control and investigational study with historical perspective; implications for chronic inflammation and sclerosus in the development of neoplasia.","volume":"29","author":"Carlson","year":"1998","journal-title":"Human Pathol"},{"key":"2023012714365889600_b7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/gyno.1994.1039","article-title":"Vulval squamous cell carcinoma and papillomaviruses: indications for 2 different aetiologies.","volume":"52","author":"Hording","year":"1994","journal-title":"Gynecol Oncol"},{"key":"2023012714365889600_b8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00008469-199512000-00008","article-title":"Squamous cell carcinoma arising in vulval lichen sclerosus: a longitudinal cohort study.","volume":"4","author":"Carli","year":"1995","journal-title":"Eur J Cancer Prev"},{"key":"2023012714365889600_b9","first-page":"323","article-title":"Carcinoma of the vulva and asymptomatic lichen sclerosus.","volume":"69","author":"Byren","year":"1993","journal-title":"Genitourin Med"},{"key":"2023012714365889600_b10","first-page":"526","article-title":"Epithelial alterations adjacent to invasive squamous cell carcinoma of the vulva.","volume":"39","author":"Gomez Rueda","year":"1994","journal-title":"J Reprod Med"},{"key":"2023012714365889600_b11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1365-2133.1994.tb04987.x","article-title":"Squamous cell carcinoma arising in vulval lichen planus.","volume":"131","author":"Lewis","year":"1994","journal-title":"Br J Dermatol"},{"key":"2023012714365889600_b12","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/00003081-198528010-00021","article-title":"Superficial invasive carcinoma of the vulva.","volume":"28","author":"Wilkinson","year":"1985","journal-title":"Clin Obstet Gynaecol"},{"key":"2023012714365889600_b13","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/1097-0142(19841001)54:7<1429::AID-CNCR2820540733>3.0.CO;2-G","article-title":"Vulvar intraepithelial neoplasia (severe atypia and carcinoma in situ). 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