{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:13:15Z","timestamp":1772169195778,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":602,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p>The t(7;11)(p15;p15) translocation is a recurrent aberration observed in acute myeloblastic leukaemia (AML) and chronic myelogenous leukaemia (CML). It has been shown that the <jats:italic>NUP98<\/jats:italic> gene at 11p15 is fused with the <jats:italic>HOXA9<\/jats:italic> gene at 7p15 in AML with t(7;11). We report the first case with CML expressing the <jats:italic>NUP98\/HOXA9<\/jats:italic> fusion transcript. A 27\u2010year\u2010old Japanese man was initially diagnosed as in the chronic phase of Philadelphia\u2010positive CML. At the diagnosis of myeloid blast crisis, the karyotype evolved to 46, XY, t(7;11)(p15;p15), t(9;22)(q34;q11). Reverse transcriptase polymerase chain reaction identified the <jats:italic>NUP98\/HOXA9<\/jats:italic> transcript, suggesting that the NUP98\/HOXA9 fusion protein could play a critical role in the progression to blast crisis.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2000.02003.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:24:20Z","timestamp":1047363860000},"page":"423-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Expression of the <i>NUP98<\/i>\/<i>HOXA9<\/i> fusion transcript in the blast crisis of Philadelphia chromosome\u2010positive chronic myelogenous leukaemia with t(7;11)(p15;p15)"],"prefix":"10.1111","volume":"109","author":[{"given":"Katsuya","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinpei","family":"Furusawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"628","article-title":"The relationship between secondary chromosomal abnormalities and blast transformation in chronic myelogenous leukemia","volume":"9","author":"Anastasi J.","year":"1995","journal-title":"Leukemia"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0296-159"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-2100.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910360606"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01588.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199905)25:1<70::AID-GCC11>3.0.CO;2-E"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0296-154"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90051-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1182\/blood.V70.5.1654.1654","article-title":"Reciprocal translocation involving the short arms of chromosomes 7 and 11, t(7p\u2010;11p+), associated with myeloid leukemia with maturation","volume":"70","author":"Sato Y.","year":"1987","journal-title":"Blood"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90038-5"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01901320"},{"key":"e_1_2_6_13_2","first-page":"625","article-title":"Molecular analysis of a case of Philadelphia chromosome\u2010positive acute myeloid leukemia","volume":"17","author":"Yoshida A.","year":"1997","journal-title":"Anticancer Research"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2141.2000.02003.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2141.2000.02003.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2141.2000.02003.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T14:30:07Z","timestamp":1698589807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2141.2000.02003.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1046\/j.1365-2141.2000.02003.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2141.2000.02003.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]},"assertion":[{"value":"2001-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}