{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:32:23Z","timestamp":1779939143750,"version":"3.53.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,20]],"date-time":"2001-12-20T00:00:00Z","timestamp":1008806400000},"content-version":"vor","delay-in-days":353,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>Iron\u2010dependent oxidative reactions in \u03b2\u2010thalassaemic erythrocyte membranes are involved in premature cell removal and anaemia. We studied 22 \u03b2\u2010thalassaemia intermedia patients (i) to assess if membrane iron accumulation influences the oxidative damage to thalassaemic cells, and (ii) to see whether the mechanisms of haemoglobin destabilization described <jats:italic>in vitro<\/jats:italic> have indicators in circulating erythrocytes. Serum non\u2010transferrin\u2010bound iron as potentially toxic iron for erythrocytes was also evaluated. Membrane\u2010bound free iron significantly correlated to bound haemichromes, suggesting a causal relation, but was poorly related to serum non\u2010transferrin iron, which seems to contribute little to damage from outside the cells. The spleen played an important role in the removal of cells with more membrane iron.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2001.02482.x","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:10:39Z","timestamp":1027678239000},"page":"48-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Membrane\u2010bound iron contributes to oxidative damage of \u03b2\u2010thalassaemia intermedia erythrocytes"],"prefix":"10.1111","volume":"112","author":[{"given":"Dario","family":"Tavazzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Duca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Graziadei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Comino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemino","family":"Fiorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Domenica","family":"Cappellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(97)00391-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01217.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/lc.1999.v133.a94241"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.4.1278.1278"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(89)90121-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1182\/blood.V88.2.705.bloodjournal882705","article-title":"Kinetics of removal and reappearance of non\u2010transferrin \u2010bound plasma iron with deferoxamine therapy","volume":"88","author":"Porter J.B.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.10.2753.2753"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1182\/blood.V82.10.3204.3204","article-title":"Nonrandom association of free iron with membranes of sickle and \u03b2\u2010thalassemic erythrocytes","volume":"82","author":"Repka T.","year":"1993","journal-title":"Blood"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05394.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116380"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.9.3948.bloodjournal8793948"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269809071545"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2141.2001.02482.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2141.2001.02482.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2141.2001.02482.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:33:16Z","timestamp":1697506396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2141.2001.02482.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1046\/j.1365-2141.2001.02482.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2141.2001.02482.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]},"assertion":[{"value":"2001-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}