{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T09:39:55Z","timestamp":1725615595032},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,20]],"date-time":"2001-12-20T00:00:00Z","timestamp":1008806400000},"content-version":"vor","delay-in-days":141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>Deletions of 13q14.3 are well known in several malignancies and are thought to be associated with tumour suppressor function. The <jats:italic>RB\u20101<\/jats:italic> gene is a tumour suppressor gene, but other loci including D13S319 and D13S25 telomeric to this within 13q14.3 are deleted in B\u2010cell chronic lymphocytic leukaemia (B\u2010CLL), multiple myeloma and non\u2010Hodgkin's lymphoma, with varying clinical significance. The fluorescence <jats:italic>in situ<\/jats:italic> hybridization screening of 22 patients with T\u2010prolymphocytic leukaemia (T\u2010PLL) for deletions of 13q14.3 revealed loss of D13S25 in 17 cases (mean 40% range 13\u201398%), with 11 patients having at least a 20% deletion. Mapping the deletions for the <jats:italic>RB\u20101<\/jats:italic>, D13S319,and D13S25 loci revealed D13S25 as the most frequently deleted marker. However, patients with only the D13S25 deletion had low percentages of cells with the deletion (12\u201313%), suggesting that loss of D13S25 on its own may not provide sufficient growth advantage. The use of the YAC 954c12, which maps immediately adjacent to D13S25, defined the telomeric border of the deletion in some of the cases. Inv(14)(q11q32) and t(14;14)(q11;q32) are characteristic of T\u2010PLL, but are also observed in premalignant T\u2010cell clones in patients with ataxia telangiectasia. Transition to overt leukaemia may result from loss of suppressor function. Thus, 13q14.3 deletions could contribute to the development of overt leukaemia in T\u2010PLL, but the involvement of more than one gene in the region cannot be excluded.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2001.02935.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:36:11Z","timestamp":1047364571000},"page":"327-332","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deletions of D13S25, D13S319 and <i>RB\u20101<\/i> mapping to 13q14.3 in T\u2010cell prolymphocytic leukaemia"],"prefix":"10.1111","volume":"114","author":[{"given":"V.","family":"Brito\u2010Babapulle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Baou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Matutes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Morilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5464"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.5008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90228-M"},{"issue":"1","key":"e_1_2_6_5_1","first-page":"15780)","article-title":"The D13S25 locus mapping to 13q14.3 is deleted in T\u2010prolymphocytic leukaemia","volume":"167","author":"Brito\u2010Babapulle V.","year":"2000","journal-title":"International Journal of Hematology"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401208"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1182\/blood.V91.4.1382","article-title":"Detailed molecular delineation of 13q14.3 loss in B\u2010Cell chronic lymphocytic leukemia","volume":"91","author":"Corcoran M.","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_8_1","first-page":"589","article-title":"13q14 deletion in non\u2010Hodgkin's lymphoma: correlation with clinicopathologic features","volume":"84","author":"Cuneo A.","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200008"},{"key":"e_1_2_6_10_1","first-page":"19","article-title":"Cytogenetics of chronic lymphocytic leukemia","volume":"25","author":"Juliusson G.","year":"1998","journal-title":"Seminars in Oncology"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(98)00357-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201643"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","unstructured":"Maljaie H. 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