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A significant elevation of plasma matrix metalloproteinase\u20109 (MMP\u20109) was observed in some ATL patients, particularly in the patients with malignant cell infiltration. MMP\u20109 was found to be secreted into the conditioned medium from all ATL cell lines examined. Moreover, the corresponding mRNA was detectable both in all ATL cell lines examined and in the majority of primary acute ATL cells, indicating that ATL cells are capable of synthesizing and secreting MMP\u20109. We previously demonstrated that a high incidence of ATL cell infiltration was closely related to a high plasma level of vascular endothelial growth factor (VEGF) produced by ATL cells themselves. This present study showed that the presence of increased plasma MMP\u20109 was closely associated with elevated plasma VEGF in ATL patients. Furthermore, we showed that both increased plasma MMP\u20109 and VEGF were significantly related to high ATL cell infiltration. All these findings strongly suggest that MMP\u20109 and VEGF act co\u2010operatively in the process of ATL cell invasion.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2002.03255.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:41:35Z","timestamp":1047364895000},"page":"94-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Matrix metalloproteinase\u20109 and vascular endothelial growth factor: a possible link in adult T\u2010cell leukaemia cell 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