{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:26:43Z","timestamp":1763746003600},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p><jats:bold>Summary.<\/jats:bold> We have carried out comparative genomic hybridization (CGH) analysis on archival biopsy material from a series of 30 UK mantle cell lymphomas. The most frequent aberrations were gains of 3q (21 cases), 6p (19 cases), 7q (8 cases), 12p (8 cases), 12q (9 cases) and 17q11q21 (8 cases), and losses of 1p13p32 (10 cases), 5p13p15.3 (9 cases), 6q14q27 (11 cases), 8p (7 cases), 11q13q23 (8 cases) and 13q (18 cases). Nineteen cases (63%) had a common region of amplification at 3q28q29, which was highly amplified in three cases, suggesting the presence of a mantle cell lymphoma (MCL)\u2010related oncogene in this region. There was a minimal common region of deletion at 6q25q26 in nine cases (30%). No MCL\u2010specific locus has previously been identified on chromosome 6 and this region may contain a tumour suppressor gene specifically implicated in the development of this subtype of lymphoma. An increased number of chromosome aberrations, gain of Xq and loss of 17p were all significantly associated with a worse prognosis. A greater understanding of the genetics of mantle cell lymphoma may allow the identification of prognostic factors which will aid the identification of appropriate treatment regimens.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2002.03260.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:42:11Z","timestamp":1047364931000},"page":"291-298","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridization"],"prefix":"10.1111","volume":"116","author":[{"given":"Jeannette E.","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael E.","family":"Hough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Goepel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bottomley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gill A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen E.","family":"Alcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Lorigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth A.","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry W.","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.2067"},{"key":"e_1_2_6_3_1","first-page":"4365","article-title":"Increased number of chromosomal imbalances and high\u2010level DNA amplifications in mantle cell lymphoma are associated with blastoid variants","volume":"93","author":"Bea S.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200003)27:3<285::AID-GCC9>3.0.CO;2-M"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199909167400"},{"key":"e_1_2_6_6_1","first-page":"589","article-title":"13q14 deletion in non\u2010Hodgkin's lymphoma: correlation with clinicopathologic features","volume":"84","author":"Cuneo A.","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1182\/blood.V93.4.1372","article-title":"Cytogenetic profile of lymphoma of follicle mantle lineage: correlation with clinicobiologic features","volume":"93","author":"Cuneo A.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.9.962"},{"key":"e_1_2_6_9_1","first-page":"4608","article-title":"Alterations of the cyclin D1\/p16\u2010pRB pathway in mantle cell lymphoma","volume":"57","author":"Dreyling M.H.","year":"1997","journal-title":"Cancer Research"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<522::AID-CNCR2820660320>3.0.CO;2-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00202476"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00228-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199808000-00005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1182\/blood.V85.4.1075.bloodjournal8541075","article-title":"A clinical analysis of 2 indolent lymphoma entities \u2013 mantle cell lymphoma and marginal zone lymphoma (including the mucosa\u2010associated lymphoid\u2010tissue and monocytoid b\u2010cell subcategories) \u2013 a southwest\u2010oncology\u2010group study","volume":"85","author":"Fisher R.I.","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_15_1","first-page":"1519.","article-title":"Partial trisomy of 3q21qter is a consistent abnormally in mantle cell lymphoma identified by comparative genomic hybridization (CGH)","volume":"88","author":"Goodacre A.M.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_16_1","first-page":"3294","article-title":"Comparative genomic hybridization (CGH) redefines deletion 6q in lymphoid malignancies","volume":"88","author":"Goodacre A.M.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.10.4302.bloodjournal87104302"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European\u2010American classification of lymphoid neoplasms \u2013 a proposal from the international lymphoma study\u2010group","volume":"84","author":"Harris N.L.","year":"1994","journal-title":"Blood"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.8.3351.bloodjournal8783351"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990160202"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80262-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870030102"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1359641"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199008000-00007"},{"key":"e_1_2_6_25_1","first-page":"361","article-title":"Molecular diagnosis of mantle cell lymphoma in paraffin\u2010embedded tissue","volume":"9","author":"Lasota J.","year":"1996","journal-title":"Modern Pathology"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/104.6.689"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.4.1664"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199804)21:4<298::AID-GCC3>3.0.CO;2-U"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01257.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199607)179:3<238::AID-PATH566>3.0.CO;2-W"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/105.5.532"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1182\/blood.V89.1.272","article-title":"Deletions and loss of expression of p16 (INK4a) and p21 (Waf1) genes are associated with aggressive variants of mantle cell lymphomas","volume":"89","author":"Pinyol M.","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00615.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/blood.V78.2.259.bloodjournal782259","article-title":"Bcl\u20101, t(11\u201314), and mantle cell\u2010derived lymphomas","volume":"78","author":"Raffeld M.","year":"1991","journal-title":"Blood"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199911)26:3<210::AID-GCC4>3.3.CO;2-A"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1182\/blood.V94.2.748","article-title":"Somatic ATM mutations indicate a pathogenic role of ATM in B\u2010cell chronic lymphocytic leukemia","volume":"94","author":"Schaffner C.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.50.1.16"},{"key":"e_1_2_6_38_1","first-page":"1700","article-title":"Mapping of 11q deletions in mantle cell lymphoma","volume":"92","author":"Stilgenbauer S.","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401216"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711630104"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401395"},{"key":"e_1_2_6_42_1","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1182\/blood.V87.11.4483.bloodjournal87114483","article-title":"Mantle cell lymphoma \u2013 an entity comes of age","volume":"87","author":"Weisenburger D.D.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_43_1","first-page":"1437","article-title":"Chromosome\u2010t (11\u201314) (q13\u2010q32) breakpoints in centrocytic lymphoma are highly localized at the bcl\u20101 major translocation cluster","volume":"7","author":"Williams M.E.","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_6_44_1","first-page":"594","article-title":"Secondary chromosome changes in mantle cell lymphoma","volume":"84","author":"Wlodarska I.","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a059155"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2141.2002.03260.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2141.2002.03260.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2141.2002.03260.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:15:06Z","timestamp":1697429706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2141.2002.03260.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1046\/j.1365-2141.2002.03260.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2141.2002.03260.x","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2]]},"assertion":[{"value":"2002-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}