{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:31:28Z","timestamp":1697430688594},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,3,25]],"date-time":"2002-03-25T00:00:00Z","timestamp":1017014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Epstein\u2013Barr virus (EBV) is frequently detected in haematological malignancies, including Burkitt's lymphomas\/leukaemias, Hodgkin's diseases and non\u2010Hodgkin's lymphomas. However, immature T\u2010cell malignancies associated with EBV have not been reported previously. We report a patient with T\u2010cell acute lymphoblastic leukaemia (T\u2010ALL), whose leukaemic cells had EBV, confirmed by Southern blotting and <jats:italic>in situ<\/jats:italic> hybridization. The EBV existed in episomal form and was detected in most leukaemic cells, but not in bystander normal B\u2010cells. The leukaemic cells, massively infiltrated into the liver and spleen, were resistant to chemotherapy. EBV might be associated with tumorigenesis of T\u2010ALL, and characteristic clinical features of the patient.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2002.03372.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:44:05Z","timestamp":1047365045000},"page":"127-129","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epstein\u2013Barr virus\u2010associated T\u2010cell acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"117","author":[{"given":"Sakura","family":"Sakajiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Kawamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Oshimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,3,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1182\/blood.V87.3.1045.bloodjournal8731045","article-title":"Epstein\u2013Barr virus genome in non\u2010Hodgkin's lymphomas occurring in immunocompetent patients: highest prevalence in non\u2010lymphoblastic T\u2010cell lymphoma and correlation with a poor prognosis","volume":"87","author":"D'Amore F.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_4_3_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. 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