{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:35:40Z","timestamp":1761100540466},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,3,25]],"date-time":"2002-03-25T00:00:00Z","timestamp":1017014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p><jats:bold>Summary.<\/jats:bold> We report a patient with spent\u2010phase polycythaemia vera (S\u2010PV) and massive splenomegaly who failed to engraft after a syngeneic granulocyte colony\u2010stimulating factor\u2010primed peripheral blood stem cell transplant (SCT), but later engrafted after splenectomy. Bone marrow (BM) showed resolution of myelofibrosis (MF) and absent endogenous erythroid colonies. This case demonstrated that (1) normal haematopoiesis can be restored after syngeneic SCT despite extensive MF, and (2) fibrosis can regress following a total body irradiation\u2010containing regimen and syngeneic SCT. As a graft\u2010versus\u2010BM stroma effect is non\u2010existent in syngeneic transplants, there may be a role for autologous SCT to obliterate MF in S\u2010PV.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2002.03387.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:44:05Z","timestamp":1047365045000},"page":"245-246","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Syngeneic stem cell transplant for spent\u2010phase polycythaemia vera: eradication of myelofibrosis and restoration of normal 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