{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:48:03Z","timestamp":1761918483136},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,5,19]],"date-time":"2002-05-19T00:00:00Z","timestamp":1021766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p><jats:bold>Summary.<\/jats:bold> Few cytogenetic data are available concerning the chromosomal constitution of post\u2010transplant lymphomas. We report two paediatric cases of trisomy 3, as a primary anomaly, in post\u2010transplant lymphoproliferative disease (PTLD) associated with B immunophenotype. Using cytogenetic analysis and fluorescence <jats:italic>in situ<\/jats:italic> hybridization on chromosome preparations, we found trisomy 3 in both patients and an extra X chromosome in one. Clinical, histological and immunophenotypical data are presented. Trisomy 3 has been observed in different types of non\u2010Hodgkin's lymphomas but it is relatively rare in B\u2010cell lymphomas, with the exception of marginal zone lymphoma and mantle cell lymphoma. To our knowledge, trisomy 3 is an uncommon cytogenetic finding in PTLD. Further cytogenetic studies of these lymphoproliferative disorders might contribute to evaluate the role of these chromosomal anomalies in the pathogenesis of this disease.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2002.03481.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:45:28Z","timestamp":1047365128000},"page":"558-562","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Trisomy 3 in two paediatric post\u2010transplant lymphomas"],"prefix":"10.1111","volume":"117","author":[{"given":"Marta S.","family":"Gallego","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bernasconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda T.","family":"D\u00e1vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Rampazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Chantada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Z.","family":"Barreiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,19]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Atlas of Genetics and Cytogenetics in Oncology and Haematology(2001)http:\/\/www.infobiogen.fr\/services\/chromocancer."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90098-9"},{"key":"e_1_2_6_4_1","first-page":"995","article-title":"Numerical cytogenetic abnormalities of chromosomes 3, 7, and 12 in marginal zone B\u2010cell lymphomas","volume":"9","author":"Brynes R.K.","year":"1996","journal-title":"Modern Pathology"},{"key":"e_1_2_6_5_1","unstructured":"Cuneo A.&Castoldi G.+3 or trisomy 3 in non\u2010Hodgkin's lymphoma (NHL). 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