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We evaluated whether short\u2010term enoxaparin administration (100\u2003IU\/kg b.i.d. for 3\u2003d) reduces the high TF levels and the hypercoagulability state, and whether it influences the fibrinolytic system in 20 unstable angina patients. On d\u20033, we observed a significant reduction in TF levels both 1\u2003h  and 4\u2003h  after the morning injection (\u221225\u00b76% and \u221221\u00b77%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001 respectively) in comparison with the base\u2010line levels. Both 1 and 4\u2003h  after the morning injection on the d\u20033, TFPI levels significantly (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001) increased (+96\u00b74%, +96\u00b79% respectively) with respect to the base\u2010line values. After enoxaparin administration, at all observation times, thrombin\u2013antithrombin complexes and prothrombin fragment F1\u2003+ 2 levels were significantly (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001) lower with respect to base\u2010line levels. We observed a slight but significant increase in tissue plasminogen activator antigen levels in preinjection samples, as well as 1\u2003h and 4\u2003h after enoxaparin administration, in comparison with the base\u2010line values. This study provides evidence that low\u2010molecular\u2010weight heparin (LMWH) administration, in addition to a reduction of hypercoagulability and a mild fibrinolytic activation, is associated with decreased TF levels, so indicating a novel mechanism of interference of LMWH with the haemostatic system.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2002.03522.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:45:28Z","timestamp":1047365128000},"page":"693-698","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tissue factor and tissue factor pathway inhibitor levels in unstable angina patients during short\u2010term low\u2010molecular\u2010weight heparin administration"],"prefix":"10.1111","volume":"117","author":[{"given":"A. 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