{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T17:29:58Z","timestamp":1719682198059},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,7,4]],"date-time":"2003-07-04T00:00:00Z","timestamp":1057276800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p><jats:bold>Summary.<\/jats:bold> Human V\u03b124<jats:sup>+<\/jats:sup> natural killer T (NKT) cells correspond to mouse V\u03b114<jats:sup>+<\/jats:sup> NKT cells, both cell types use an invariant T\u2010cell receptor\u2010\u03b1 chain and are activated by glycolipids in a CD1d\u2010dependent manner. Mouse V\u03b114<jats:sup>+<\/jats:sup> NKT cells have been reported to have an antitumour effect <jats:italic>in vivo<\/jats:italic>. Human V\u03b124<jats:sup>+<\/jats:sup> NKT cells can kill a proportion of tumour cells in a CD1d\u2010dependent manner <jats:italic>in vitro<\/jats:italic>. We report here that many human leukaemic T\u2010cell lines express CD1d and can be directly killed by V\u03b124<jats:sup>+<\/jats:sup> NKT cells. This killing activity was enhanced in the presence of \u03b1\u2010galactosylceramide (\u03b1\u2010GalCer), a ligand of V\u03b124<jats:sup>+<\/jats:sup> NKT cells. Moreover, primary leukaemic T cells from five of eight T\u2010cell acute lymphoblastic leukaemia (T\u2010ALL) patients expressed CD1d and were good targets of V\u03b124<jats:sup>+<\/jats:sup> NKT cells. This cytotoxicity was increased in the presence of \u03b1\u2010GalCer. Our results suggest that T\u2010ALL is a good candidate for V\u03b124<jats:sup>+<\/jats:sup> NKT\u2010cell\u2010based immuno\u2010cell therapy.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2003.04429.x","type":"journal-article","created":{"date-parts":[[2003,7,4]],"date-time":"2003-07-04T14:17:14Z","timestamp":1057328234000},"page":"231-239","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["V\u03b124<sup>+<\/sup> natural killer T\u2010cell responses against T\u2010acute lymphoblastic leukaemia cells: implications for 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