{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T08:48:28Z","timestamp":1794300508690,"version":"4.9.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,7,4]],"date-time":"2003-07-04T00:00:00Z","timestamp":1057276800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p><jats:bold>Summary.<\/jats:bold> Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer with a cure rate of approximately 80%. Relapse occurs despite treatment stratification based on clinical criteria. Relapse risk in ALL may be related to simple nucleotide polymorphisms (SNPs) of enzymes that metabolize chemotherapeutic agents. We evaluated whether SNPs in the cytochrome P450 3A family (<jats:italic>CYP3A4<\/jats:italic>*<jats:italic>1B<\/jats:italic>, <jats:italic>CYP3A5<\/jats:italic>*<jats:italic>3<\/jats:italic> and <jats:italic>CYP3A5<\/jats:italic>*<jats:italic>6<\/jats:italic>) were associated with relapse risk on a national Children's Cancer Group (CCG) paediatric ALL trial (CCG\u20101891). CCG\u20101891 enrolled 1204 patients, and obtained both relapse and toxicity data prospectively. One hundred and twenty\u2010four relapsed patients and 409 non\u2010relapsed patients were assayed for each SNP. <jats:italic>CYP3A<\/jats:italic> variants were not associated with an increased risk of relapse. However, patients with the <jats:italic>CYP3A4<\/jats:italic>*<jats:italic>1B<\/jats:italic> and <jats:italic>CYP3A5<\/jats:italic>*<jats:italic>3<\/jats:italic> genotypes had a decreased risk of peripheral neuropathy that was statistically significant on univariate analysis. After correction for multiple comparisons, the association between <jats:italic>CYP3A<\/jats:italic>*<jats:italic>1B<\/jats:italic> and <jats:italic>CYP3A5<\/jats:italic>*<jats:italic>3<\/jats:italic> genotypes approached, but did not reach, statistical significance. CYP3 genotypes may not significantly modify the risk of relapse in childhood ALL, but may modify the risk of toxicity.<\/jats:p>","DOI":"10.1046\/j.1365-2141.2003.04430.x","type":"journal-article","created":{"date-parts":[[2003,7,4]],"date-time":"2003-07-04T14:16:53Z","timestamp":1057328213000},"page":"240-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["CYP3A genotypes and treatment response in paediatric acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"122","author":[{"given":"Richard","family":"Aplenc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Glatfelter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rappaport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"La","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital","family":"Cnaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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