{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:08:36Z","timestamp":1777529316438,"version":"3.51.4"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Anastomotic dehiscence is common after surgery for colonic obstruction. The strength of an anastomosis is dependent on collagen, which is degraded by matrix metalloproteinases (MMPs). The aim of this study was to determine the distribution of the MMPs and their inhibitor, tissue inhibitor of metalloproteinases (TIMP) 1 in an experimental model of colonic obstruction, with and without resection and anastomosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The distal colon of rabbits was obstructed with a Silastic ring for 24 h and then either the ring was removed or the obstructed segment was resected and an anastomosis formed. Rabbits were killed immediately or at intervals for up to 7 days after operation. The distribution of the MMPs and TIMP-1 was examined by indirect immunofluorescence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>MMPs and TIMP-1 were present throughout the descending colon for 24 h in both groups. They persisted to the third day in rabbits with an anastomosis but by day 7 were restricted to the suture line. Their presence correlated with microscopic damage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The extensive distribution of the MMPs suggests that these enzymes contribute to anastomotic dehiscence, but only in the immediate postoperative period.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.1998.00550.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T06:58:10Z","timestamp":1047365890000},"page":"72-75","source":"Crossref","is-referenced-by-count":20,"title":["Effect of colonic obstruction on the distribution of matrix metalloproteinases during anastomotic healing"],"prefix":"10.1093","volume":"85","author":[{"given":"F J","family":"Savage","sequence":"first","affiliation":[{"name":"Department of Surgery, University College London Medical School , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L P","family":"Lacombe","sequence":"additional","affiliation":[{"name":"Department of Surgery, University College London Medical School , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"Hembry","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Strangeways Research Laboratory , Cambridge,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P B","family":"Boulos","sequence":"additional","affiliation":[{"name":"Department of Surgery, University College London Medical School , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"2024092914004527300_bib1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/bjs.1800600612","article-title":"Aetiology of disruption of intestinal anastomoses","volume":"60","author":"Irvin","year":"1973","journal-title":"Br J Surg"},{"key":"2024092914004527300_bib2","first-page":"296","article-title":"Obstructive colonic cancer","volume":"38","author":"Papachristodoulou","year":"1993","journal-title":"J R Coll Surg Edinb"},{"key":"2024092914004527300_bib3","first-page":"502","article-title":"Management of obstructing lesions of the left colon by resection, on-table lavage, and primary anastomosis","volume":"114","author":"Stewart","year":"1993","journal-title":"Surgery"},{"key":"2024092914004527300_bib4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0002-9610(99)80185-8","article-title":"The role of one-stage surgery in acute left-sided colonic obstruction","volume":"169","author":"Lau","year":"1995","journal-title":"Am J Surg"},{"key":"2024092914004527300_bib5","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/00000441-188710000-00010","article-title":"Circular suture of the intestine \u2013 an experimental study","volume":"94","author":"Halsted","year":"1887","journal-title":"Am J Med Sci"},{"key":"2024092914004527300_bib6","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/bjs.1800571206","article-title":"Collagenase activity in the gastro-intestinal tract","volume":"57","author":"Hawley","year":"1970","journal-title":"Br J Surg"},{"key":"2024092914004527300_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0002-9610(70)90002-4","article-title":"The cut gut","volume":"119","author":"Dunphy","year":"1970","journal-title":"Am J Surg"},{"key":"2024092914004527300_bib8","first-page":"741","article-title":"Reappraisal of the healing process of anastomosis of the colon","volume":"138","author":"Irvin","year":"1974","journal-title":"Surg Gynecol Obstet"},{"key":"2024092914004527300_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9610(78)90062-4","article-title":"Healing of experimental colonic anastomoses. 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