{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:15:22Z","timestamp":1793222122728,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Anomalous pancreaticobiliary junction (APBJ) without congenital choledochal cyst (CCC) carries a high risk of gallbladder carcinoma development. The aim of this study was to obtain information allowing early diagnosis and appropriate management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The clinical features, imaging findings and surgical outcome of 18 patients with APBJ without CCC were analysed retrospectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fourteen patients had symptoms, including those of acute pancreatitis (five patients). In 16 patients the gallbladder showed abnormalities, including carcinoma (eight) and mucosal hyperplasia (11). Ultrasonography detected gallbladder carcinoma with 100 per cent sensitivity and mucosal hyperplasia with 91 per cent sensitivity. A long common channel was demonstrated by endoscopic retrograde cholangiopancreatography (ERCP) in all patients, endoscopic ultrasonography in nine of ten, and magnetic resonance cholangiopancreatography (MRCP) in five of five. Five of eight patients with gallbladder carcinoma underwent extended cholecystectomy with bile duct excision. Three patients with cancer and eight with no cancer had cholecystectomy alone. None developed bile duct carcinoma or acute pancreatitis after operation. All patients without malignancy remained asymptomatic for a mean follow-up period of 4\u00b77 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Prophylactic cholecystectomy is recommended for patients with APBJ without CCC. For early diagnosis of APBJ, gallbladder abnormalities on ultrasonography or acute pancreatitis of unknown aetiology should prompt further investigation with ERCP or less invasive imaging modalities such as endoscopic ultrasonography and MRCP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.1998.00744.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T07:01:54Z","timestamp":1047366114000},"page":"911-916","source":"Crossref","is-referenced-by-count":66,"title":["Anomalous pancreaticobiliary junction without congenital choledochal cyst"],"prefix":"10.1093","volume":"85","author":[{"given":"M","family":"Sugiyama","sequence":"first","affiliation":[{"name":"First Department of Surgery, Kyorin University School of Medicine , 6-20-2 Shinkawa, Mitaka, Tokyo 181,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Atomi","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Kyorin University School of Medicine , 6-20-2 Shinkawa, Mitaka, Tokyo 181,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"2024092914222826500_bib1","first-page":"231","article-title":"Congenital choledochal cyst: new etiology concept based on anomalous relationships of the common bile duct and pancreatic bulb","volume":"12","author":"Babitt","year":"1969","journal-title":"Ann Radiol"},{"key":"2024092914222826500_bib2","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/0016-5085(85)90641-9","article-title":"Association of gallbladder carcinoma and anomalous pancreatobiliary ductal union","volume":"89","author":"Kimura","year":"1985","journal-title":"Gastroenterology"},{"key":"2024092914222826500_bib3","first-page":"69","article-title":"Nationwide survey of cases of choledochal cyst. 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