{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:38:18Z","timestamp":1775716698862,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100015638","name":"Japanese Breast Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015638","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health and Welfare of Japan","award":["10-3"],"award-info":[{"award-number":["10-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The purpose of the present study was to evaluate the usefulness of intraoperative imprint cytology and frozen sectioning of sentinel lymph nodes in patients with clinically node-negative breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sentinel node biopsy was performed in 101 patients with stage I or II breast cancer with clinically negative nodes using a dye-guided method. Intraoperative evaluation of sentinel node involvement by imprint cytology and frozen sectioning was compared with the final histopathological results of permanent sections. Tumour-negative nodes in paraffin sections stained by haematoxylin and eosin were further studied using an anticytokeratin antibody.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The results of imprint cytology and frozen-section analysis were compared with those of haematoxylin and eosin-stained sections. The sensitivity, specificity and overall accuracy of imprint cytology were 96\u00b70, 90\u00b78 and 92\u00b71 per cent respectively, and those of frozen-section examination were 52\u00b70, 100 and 88\u00b71 per cent. Ten sentinel nodes were tumour positive on imprint cytology and tumour negative on stained paraffin sections. Micrometastasis was found in eight of these nodes on immunohistochemistry. Taking these immunohistological results into consideration, the final sensitivity, specificity and overall accuracy of imprint cytology were 90\u00b79, 98\u00b75 and 96\u00b70 per cent respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Intraoperative imprint cytology is a useful method for evaluating the status of sentinel nodes and is more accurate than frozen-section analysis. In addition, imprint cytology can detect micrometastasis more accurately than conventional haematoxylin and eosin-stained sectioning.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.2000.01423.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T07:14:17Z","timestamp":1047366857000},"page":"597-601","source":"Crossref","is-referenced-by-count":159,"title":["Intraoperative sentinel lymph node examination by imprint cytology and frozen sectioning during breast surgery"],"prefix":"10.1093","volume":"87","author":[{"given":"K","family":"Motomura","sequence":"first","affiliation":[{"name":"Department of Surgery, Osaka Medical Centre for Cancer and Cardiovascular Diseases , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Inaji","sequence":"additional","affiliation":[{"name":"Department of Surgery, Osaka Medical Centre for Cancer and Cardiovascular Diseases , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Komoike","sequence":"additional","affiliation":[{"name":"Department of Surgery, Osaka Medical Centre for Cancer and Cardiovascular Diseases , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kasugai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Osaka Medical Centre for Cancer and Cardiovascular Diseases , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nagumo","sequence":"additional","affiliation":[{"name":"Department of Cytology, Osaka Medical Centre for Cancer and Cardiovascular Diseases , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Osaka University Medical School , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Osaka Medical Centre for Cancer and Cardiovascular Diseases , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"2024093004101427000_bib1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM198503143121102","article-title":"Ten-year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without radiation","volume":"312","author":"Fisher","year":"1985","journal-title":"N Engl J Med"},{"key":"2024093004101427000_bib2","first-page":"669","volume-title":"Diseases of the Breast","author":"Haagensen","year":"1971","edition":"2nd"},{"key":"2024093004101427000_bib3","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0959-8049(95)00603-6","article-title":"Isolated axillary recurrences after conservative treatment of breast cancer","volume":"32A","author":"Renolleau","year":"1996","journal-title":"Eur J Cancer"},{"key":"2024093004101427000_bib4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0360-3016(93)90274-Y","article-title":"Regional nodal management and patterns of failure following conservative surgery and radiation therapy for stage I and II breast cancer","volume":"26","author":"Halverson","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2024093004101427000_bib5","first-page":"407","article-title":"Breast cancer; risk of axillary recurrence in node-negative patients following partial dissection of the axilla","volume":"14","author":"Graversen","year":"1988","journal-title":"Eur J Surg Oncol"},{"key":"2024093004101427000_bib6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/bjs.1800720511","article-title":"Probability of false negative nodal status in conjunction with partial axillary dissection in breast cancer","volume":"72","author":"Kjaergaard","year":"1985","journal-title":"Br J Surg"},{"key":"2024093004101427000_bib7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/BF01556846","article-title":"The Guy's trial of treatment of early breast cancer","volume":"1","author":"Hayward","year":"1977","journal-title":"World J Surg"},{"key":"2024093004101427000_bib8","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0140-6736(92)91591-U","article-title":"Value of axillary dissection in addition to lumpectomy and radiotherapy in early breast cancer. 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