{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:15:19Z","timestamp":1791342919233,"version":"4.3.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pancreatic resections can be performed with great safety. However, the morbidity rate is reported to be 40\u201360 per cent with a high prevalence of pancreatic complications. The aim of this study was to analyse complications after pancreatic head resection, with particular attention to morbidity and pancreatic fistula.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From November 1993 to May 1999, perioperative and postoperative data from 331 consecutive patients undergoing pancreatic head resection were recorded prospectively. Data were analysed and grouped according to the procedure performed: classic Whipple resection, pylorus-preserving pancreatoduodenectomy (PPPD) or duodenum-preserving pancreatic head resection (DPPHR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Pancreatic head resection had a mortality rate of 2\u00b71 per cent; the difference in mortality rate between the three groups (0\u00b79\u20133\u00b70 per cent) was not significant. Total and local morbidity rates were 38\u00b74 and 28 per cent respectively. DPPHR had a lower morbidity, both local and systemic, than pancreatoduodenectomy. The prevalence of pancreatic fistula was 2\u00b71 per cent in 331 patients, and was not dependent on the procedure or the aetiology of the disease. Reoperations were performed in 3\u00b79 per cent of patients, predominantly for bleeding and non-pancreatic fistula. None of the patients with pancreatic fistula required reoperation or died in the postoperative course.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A standardized technique and a continuing effort to improve perioperative management may be responsible for low mortality and surgical morbidity rates after pancreatic head resection. Pancreatic complications occur with Whipple, PPPD and DPPHR procedures with a similar prevalence. Pancreatic fistula no longer seems to be a major problem after pancreatic head resection and rarely necessitates surgical treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.2000.01465.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T07:15:13Z","timestamp":1047366913000},"page":"883-889","source":"Crossref","is-referenced-by-count":307,"title":["Pancreatic fistula after pancreatic head resection"],"prefix":"10.1093","volume":"87","author":[{"given":"M W","family":"B\u00fcchler","sequence":"first","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, Inselspital, University of Bern , 3010 Bern,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Friess","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, Inselspital, University of Bern , 3010 Bern,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, Inselspital, University of Bern , 3010 Bern,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kulli","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, Inselspital, University of Bern , 3010 Bern,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Wagener","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, Inselspital, University of Bern , 3010 Bern,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Z'graggen","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery, Inselspital, University of Bern , 3010 Bern,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"2024093004091365300_bib1","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1046\/j.1365-2168.1998.00745.x","article-title":"Postoperative weight gain after standard Whipple's procedure versus pylorus-preserving pancreatoduodenectomy: the influence of tumour status","volume":"85","author":"van Berge Henegouwen","year":"1998","journal-title":"Br J Surg"},{"key":"2024093004091365300_bib2","first-page":"1370","article-title":"Low mortality following resection for pancreatic and periampullary tumours in 1026 patients: UK survey of specialist pancreatic units. 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