{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:52:56Z","timestamp":1761893576532},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hyaluronic acid (HA) agents reduce postsurgical adhesion formation. The effect of their perioperative administration on early anastomotic healing is unknown. This study investigated the influence of two HA-containing agents on the development of strength in colonic anastomosis during the first postoperative week, both in normal rats and in rats with bacterial peritonitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In 90 male Wistar rats a 1-cm segment was resected from the descending colon and an end-to-end anastomosis was constructed. In 108 rats a bacterial peritonitis was induced using caecal ligation and puncture (CLP). Some 24 h after CLP the abdomen was reopened, the caecum was taken out and, after resection of a 1-cm segment, an anastomosis was made. Animals in both groups were randomized to receive either an HA\u2013carboxymethylcellulose (CMC) bioresorbable membrane, 0\u00b74 per cent HA solution or no treatment. One-third of each group was killed at day 1, 3 and 7 after operation. Cultures were taken from the abdominal cavity for microbiological analysis in half of the animals. Subsequently, both bursting pressure and breaking strength were determined as parameters for anastomotic strength.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>No differences in anastomotic bursting pressure or breaking strength were found between the experimental groups and their controls. In addition, there was no significant difference in the number of bacteria cultured from the abdominal cavity between rats treated with HA and controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Neither HA-CMC bioresorbable membrane nor 0\u00b74 per cent HA solution interferes with the development of early anastomotic strength in the colon, and can therefore be safely used to prevent intra-abdominal adhesion formation after performing bowel anastomosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.2000.01506.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T07:16:05Z","timestamp":1047366965000},"page":"1222-1228","source":"Crossref","is-referenced-by-count":20,"title":["Hyaluronic acid-based agents do not affect anastomotic strength in the rat colon, in either the presence or absence of bacterial peritonitis"],"prefix":"10.1093","volume":"87","author":[{"given":"M M P J","family":"Reijnen","sequence":"first","affiliation":[{"name":"Department of Surgery, University Hospital Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B M","family":"de Man","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V A","family":"Postma","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F G M","family":"Meis","sequence":"additional","affiliation":[{"name":"Medical Microbiology, University Hospital Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"van Goor","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2024093005355814200_bib1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00003081-199106000-00023","article-title":"Adhesiolysis","volume":"34","author":"Hershlag","year":"1991","journal-title":"Clin Obstet Gynecol"},{"volume-title":"High incidence and morbidity of inadvertent enterotomy dividing adhesions at abdominal reoperation","author":"van der Krabben","key":"2024093005355814200_bib2"},{"key":"2024093005355814200_bib3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0039-6109(05)70574-0","article-title":"Clinical problem of intraperitoneal postsurgical adhesion formation following general surgery and the use of adhesion prevention barriers","volume":"77","author":"DeCherney","year":"1997","journal-title":"Surg Clin North Am"},{"key":"2024093005355814200_bib4","first-page":"10","article-title":"Biochemical events in peritoneal tissue repair","volume":"577","author":"diZerega","year":"1997","journal-title":"Eur J Surg"},{"key":"2024093005355814200_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/978-3-642-60433-1_39","volume-title":"Peritoneal Adhesions","author":"Kowalczyk","year":"1997"},{"key":"2024093005355814200_bib6","first-page":"297","article-title":"Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study","volume":"183","author":"Becker","year":"1996","journal-title":"J Am Coll Surg"},{"key":"2024093005355814200_bib7","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0015-0282(16)58716-0","article-title":"Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Seprafilm Adhesion Study Group","volume":"66","author":"Diamond","year":"1996","journal-title":"Fertil Steril"},{"key":"2024093005355814200_bib8","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0015-0282(98)00057-0","article-title":"Reduction of de novo postsurgical adhesions by intraoperative precoating with Sepracoat (HAL-C) solution: a prospective, randomized, blinded, placebo-controlled multicenter study. The Sepracoat Adhesion Study Group","volume":"69","author":"Diamond","year":"1998","journal-title":"Fertil Steril"},{"key":"2024093005355814200_bib9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1006\/jsre.1995.1218","article-title":"Prevention of tissue injury and postsurgical adhesions by precoating tissues with hyaluronic acid solutions","volume":"59","author":"Burns","year":"1995","journal-title":"J Surg Res"},{"key":"2024093005355814200_bib10","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0015-0282(16)54558-0","article-title":"Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model","volume":"56","author":"Urman","year":"1991","journal-title":"Fertil Steril"},{"key":"2024093005355814200_bib11","first-page":"818","article-title":"Prevention of adhesions by Seprafilm, an absorbable adhesion barrier: an incisional hernia model in rats","volume":"63","author":"Alponat","year":"1997","journal-title":"Am Surg"},{"key":"2024093005355814200_bib12","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1001\/archsurg.134.9.997","article-title":"Prevention of intra-abdominal abscesses and adhesions by a hyaluronic acid solution in a rat peritonitis model","volume":"134","author":"Reijnen","year":"1999","journal-title":"Arch Surg"},{"key":"2024093005355814200_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2796.1997.00170.x","article-title":"Hyaluronan: its nature, distribution, functions, and turnover","volume":"242","author":"Fraser","year":"1997","journal-title":"J Intern Med"},{"key":"2024093005355814200_bib14","first-page":"41","volume-title":"The Biology of Hyaluronan","author":"Fraser","year":"1989"},{"key":"2024093005355814200_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0934-8832(11)80110-1","article-title":"Hyaluronic acid modulates proliferation, collagen and protein synthesis of cultured fetal fibroblasts","volume":"13","author":"Mast","year":"1993","journal-title":"Matrix"},{"key":"2024093005355814200_bib16","first-page":"259","article-title":"Extracellular matrix, supramolecular organisation and shape","volume":"187","author":"Scott","year":"1995","journal-title":"J Anat"},{"key":"2024093005355814200_bib17","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/BF02051930","article-title":"Healing of experimental intestinal anastomoses. Parameters for repair","volume":"33","author":"Hendriks","year":"1990","journal-title":"Dis Colon Rectum"},{"key":"2024093005355814200_bib18","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/archsurg.1994.01420350077010","article-title":"Loss of colonic structural collagen impairs healing during intra-abdominal sepsis","volume":"129","author":"Ahrendt","year":"1994","journal-title":"Arch Surg"},{"key":"2024093005355814200_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-4804(80)90037-2","article-title":"Sepsis and septic shock \u2013 a review of laboratory models and a proposal","volume":"29","author":"Wichterman","year":"1980","journal-title":"J Surg Res"},{"key":"2024093005355814200_bib20","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/bjc.1995.355","article-title":"Post-operative levamisole may compromise early healing of experimental intestinal anastomoses","volume":"72","author":"de Waard","year":"1995","journal-title":"Br J Cancer"},{"key":"2024093005355814200_bib21","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1046\/j.1365-2168.1998.00841.x","article-title":"Small bowel obstruction after total or subtotal colectomy: a 10-year retrospective review","volume":"85","author":"Nieuwenhuijzen","year":"1998","journal-title":"Br J Surg"},{"key":"2024093005355814200_bib22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3109\/08941939409016509","article-title":"Effect of hyaluronic acid solution on healing of bowel anastomoses","volume":"7","author":"Holzman","year":"1994","journal-title":"J Invest Surg"},{"key":"2024093005355814200_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/08941939509023140","article-title":"Novel antiadhesion barrier does not prevent anastomotic healing in a rabbit model","volume":"8","author":"Medina","year":"1995","journal-title":"J Invest Surg"},{"key":"2024093005355814200_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000008552","article-title":"Effect of fibrin glue on small and large bowel anastomoses in the rat","volume":"30","author":"Shinohara","year":"1998","journal-title":"Eur Surg Res"},{"key":"2024093005355814200_bib25","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1007\/BF02055171","article-title":"Effect of fibrin glue on irradiated colonic anastomoses","volume":"40","author":"Karahasanoglu","year":"1997","journal-title":"Dis Colon Rectum"},{"key":"2024093005355814200_bib26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/archsurg.1988.01400260118015","article-title":"Fibrin sealant in high-risk colonic anastomoses","volume":"123","author":"Houston","year":"1988","journal-title":"Arch Surg"},{"key":"2024093005355814200_bib27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/bjs.1800780117","article-title":"Effect of fibrin sealant on the healing colonic anastomosis in the rat","volume":"78","author":"Van der Ham","year":"1991","journal-title":"Br J Surg"},{"key":"2024093005355814200_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0002-9610(99)80082-8","article-title":"Intra-abdominal sepsis impairs colonic reparative collagen synthesis","volume":"171","author":"Ahrendt","year":"1996","journal-title":"Am J Surg"},{"key":"2024093005355814200_bib29","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/00000658-199002000-00003","article-title":"Tissue plasminogen activator reverses the deleterious effect of infection on colonic wound healing","volume":"211","author":"Houston","year":"1990","journal-title":"Ann Surg"},{"key":"2024093005355814200_bib30","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00000658-195211000-00006","article-title":"Experimental study of physical factors, including fibrin formation, influencing the spread of fluids and small particles within and from the peritoneal cavity of the dog","volume":"136","author":"Zinsser","year":"1952","journal-title":"Ann Surg"},{"key":"2024093005355814200_bib31","first-page":"41","article-title":"Fibrin in peritonitis. I. Beneficial and adverse effects of fibrin in experimental E. coli peritonitis","volume":"88","author":"Ahrenholz","year":"1980","journal-title":"Surgery"},{"key":"2024093005355814200_bib32","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/bjs.1800790617","article-title":"Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat","volume":"79","author":"van der Ham","year":"1992","journal-title":"Br J Surg"},{"key":"2024093005355814200_bib33","first-page":"407","article-title":"Effect of recombinant tissue plasminogen activator on intra-abdominal abscess formation in rats with generalized peritonitis","volume":"179","author":"van Goor","year":"1994","journal-title":"J Am Coll Surg"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2168.2000.01506.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2168.2000.01506.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/87\/9\/1222\/59439313\/bjs127.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/87\/9\/1222\/59439313\/bjs127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:36:19Z","timestamp":1727674579000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/87\/9\/1222\/6268831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,1]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2000,9,1]]},"published-print":{"date-parts":[[2000,9,1]]}},"URL":"https:\/\/doi.org\/10.1046\/j.1365-2168.2000.01506.x","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[2000,9]]},"published":{"date-parts":[[2000,9,1]]}}}