{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:49:13Z","timestamp":1760266153581},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Recently, the diagnosis of superficial oesophageal carcinoma has increased markedly in Japan as a result of advances in endoscopy. A number of these carcinomas have proved to be multiple.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Some 359 patients with superficial squamous cell carcinoma of the oesophagus who underwent oesophagectomy (n = 276) or endoscopic mucosal resection (EMR) (n = 83) were reviewed retrospectively. The clinicopathological features of patients with multiple superficial oesophageal carcinoma were compared with those of patients with a single superficial oesophageal carcinoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 359 patients, 99 (28 per cent) had multiple superficial oesophageal carcinoma. The male: female ratio in patients with multiple carcinoma was 98: 1, compared with 5\u00b73: 1 for those with a single carcinoma (n = 260) (P = 0\u00b70001). The incidence of tobacco and alcohol use was significantly higher in the patients with multiple carcinoma than in those with a single carcinoma (P = 0\u00b704 and P = 0\u00b703 respectively). The incidence of pharyngeal malignancy was also significantly higher in patients with multiple carcinoma (P = 0\u00b702).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The high incidence of multiple superficial oesophageal carcinoma indicates a need for careful evaluation of the oesophagus at the time of initial diagnosis, treatment and follow-up for superficial oesophageal carcinoma. Male sex, smoking, alcohol use and the presence of pharnygeal malignancy are high-risk factors for multiple superficial oesophageal carcinoma.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1046\/j.1365-2168.2000.01588.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T07:12:40Z","timestamp":1047366760000},"page":"1712-1715","source":"Crossref","is-referenced-by-count":11,"title":["Clinicopathological study of multiple superficial oesophageal carcinoma"],"prefix":"10.1093","volume":"87","author":[{"given":"A","family":"Kanamoto","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Cancer Center Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Cancer Center Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Pathology Division, National Cancer Center Research Institute , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Tachimori","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Cancer Center Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Cancer Center Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Cancer Center Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2024093005070619800_bib1","first-page":"813","article-title":"Shiller's test: an aid in esophagoscopic diagnosis","volume":"60","author":"Brodmerkel","year":"1971","journal-title":"Gastroenterology"},{"key":"2024093005070619800_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1055\/s-2007-1021710","article-title":"In situ carcinoma of the esophagus. Macroscopic study with particular reference to the Lugol test","volume":"12","author":"Mandard","year":"1980","journal-title":"Endoscopy"},{"key":"2024093005070619800_bib3","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1002\/1097-0142(19931115)72:10<2879::AID-CNCR2820721004>3.0.CO;2-Q","article-title":"Cervical, mediastinal, and abdominal lymph node dissection (three-field dissection) for superficial carcinoma of the thoracic esophagus","volume":"72","author":"Kato","year":"1993","journal-title":"Cancer"},{"key":"2024093005070619800_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/den.1996.8.3.175","article-title":"Endoscopic mucosal resection for early esophageal cancer \u2013 indication and techniques","volume":"8","author":"Makuuchi","year":"1996","journal-title":"Dig Endosc"},{"key":"2024093005070619800_bib5","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/1097-0142(19901201)66:11<2319::AID-CNCR2820661111>3.0.CO;2-1","article-title":"Superficial esophageal carcinoma. Surgical treatment and the results","volume":"66","author":"Kato","year":"1990","journal-title":"Cancer"},{"key":"2024093005070619800_bib6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0039-6060(98)70165-5","article-title":"Treatment of superficial cancer of the esophagus: a summary of responses to a questionnaire on superficial cancer of the esophagus in Japan","volume":"123","author":"Kodama","year":"1998","journal-title":"Surgery"},{"key":"2024093005070619800_bib7","volume-title":"TNM Classification of Malignant Tumours","author":"Sobin","year":"1997","edition":"5th"},{"edition":"9th","volume-title":"Guidelines for Clinical and Pathologic Studies on Carcinoma of the Esophagus","year":"1999","key":"2024093005070619800_bib8"},{"key":"2024093005070619800_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assn"},{"key":"2024093005070619800_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples","volume":"35","author":"Peto","year":"1977","journal-title":"Br J Cancer"},{"key":"2024093005070619800_bib11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc"},{"key":"2024093005070619800_bib12","first-page":"706","article-title":"Clinicopathologic study of early stage esophageal carcinoma","volume":"105","author":"Sugimachi","year":"1989","journal-title":"Surgery"},{"key":"2024093005070619800_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0960-7404(93)90014-P","article-title":"Multiple primary carcinoma of the oesophagus","volume":"2","author":"Mizobuchi","year":"1993","journal-title":"Surg Oncol"},{"key":"2024093005070619800_bib14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1620\/tjem.124.117","article-title":"Epithelial dysplasia in cancerous and noncancerous esophagi","volume":"124","author":"Sato","year":"1978","journal-title":"Tohoku J Exp Med"},{"key":"2024093005070619800_bib15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/jso.2930460404","article-title":"Lugol stain for intraoperative determination of the proximal surgical margin of the esophagus","volume":"46","author":"Sugimachi","year":"1991","journal-title":"J Surg Oncol"},{"key":"2024093005070619800_bib16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/1097-0142(196103\/04)14:2<389::AID-CNCR2820140220>3.0.CO;2-E","article-title":"A study of etiological factors in cancer of the esophagus","volume":"14","author":"Wynder","year":"1961","journal-title":"Cancer"},{"key":"2024093005070619800_bib17","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0003-4975(98)00177-5","article-title":"Multiple primary cancers in esophageal squamous cell carcinoma: incidence and implications","volume":"65","author":"Poon","year":"1998","journal-title":"Ann Thorac Surg"},{"key":"2024093005070619800_bib18","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1136\/bmj.317.7162.844","article-title":"Population based cohort study of the association between alcohol intake and cancer of the upper digestive tract","volume":"317","author":"Gronbaek","year":"1998","journal-title":"BMJ"},{"key":"2024093005070619800_bib19","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/1097-0142(19930815)72:4<1369::AID-CNCR2820720436>3.0.CO;2-L","article-title":"Tobacco smoking, alcohol drinking, and cancer of the oral cavity and oropharynx among US veterans","volume":"72","author":"Mashberg","year":"1993","journal-title":"Cancer"},{"key":"2024093005070619800_bib20","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/BF00054158","article-title":"A population-based case\u2013control study of the relationship between cigarette smoking and nasopharyngeal cancer (United States)","volume":"6","author":"Zhu","year":"1995","journal-title":"Cancer Causes Control"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2168.2000.01588.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2168.2000.01588.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/87\/12\/1712\/59438173\/bjs22.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/87\/12\/1712\/59438173\/bjs22.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:09:12Z","timestamp":1727672952000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/87\/12\/1712\/6268628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,1]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2000,12,1]]},"published-print":{"date-parts":[[2000,12,1]]}},"URL":"https:\/\/doi.org\/10.1046\/j.1365-2168.2000.01588.x","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[2000,12]]},"published":{"date-parts":[[2000,12,1]]}}}